CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021918
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proliferating cellular nuclear antigen 1 
Protein Synonyms/Alias
 PCNA 1 
Gene Name
 PCNA 
Gene Synonyms/Alias
 PCNA1; At1g07370; F22G5.29 
Created Date
 July 27, 2013 
Organism
 Arabidopsis thaliana (Mouse-ear cress) 
NCBI Taxa ID
 3702 
Lysine Modification
Position
Peptide
Type
References
13LVQGSLLKKVLESIKsumoylation[1]
14VQGSLLKKVLESIKDsumoylation[1]
20KKVLESIKDLVNDANsumoylation[1]
217RYMNSFTKATPLSDTsumoylation[1]
240LPVVVEYKVAEMGYIsumoylation[1]
254IRYYLAPKIEEEEDTsumoylation[1]
Reference
 [1] Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites.
 Strzalka W, Labecki P, Bartnicki F, Aggarwal C, Rapala-Kozik M, Tani C, Tanaka K, Gabrys H.
 J Exp Bot. 2012 May;63(8):2971-83. [PMID: 22330895
Functional Description
 This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). 
Sequence Annotation
 DNA_BIND 61 80 Potential.  
Keyword
 3D-structure; Complete proteome; DNA replication; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 263 AA 
Protein Sequence
MLELRLVQGS LLKKVLESIK DLVNDANFDC SSTGFSLQAM DSSHVALVSL LLRSEGFEHY 60
RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGGDTVT FMFESPTQDK IADFEMKLMD 120
IDSEHLGIPD AEYHSIVRMP SNEFSRICKD LSSIGDTVVI SVTKEGVKFS TAGDIGTANI 180
VLRQNTTVDK PEDAIVIEMK EPVSLSFALR YMNSFTKATP LSDTVTISLS SELPVVVEYK 240
VAEMGYIRYY LAPKIEEEED TNP 263 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:TAIR.
 GO:0005730; C:nucleolus; IDA:TAIR.
 GO:0043626; C:PCNA complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0051726; P:regulation of cell cycle; ISS:TAIR.
 GO:0006275; P:regulation of DNA replication; IEA:InterPro. 
Interpro
 IPR000730; Pr_cel_nuc_antig.
 IPR022649; Pr_cel_nuc_antig_C.
 IPR022659; Pr_cel_nuc_antig_CS.
 IPR022648; Pr_cel_nuc_antig_N. 
Pfam
 PF02747; PCNA_C
 PF00705; PCNA_N 
SMART
  
PROSITE
 PS01251; PCNA_1
 PS00293; PCNA_2 
PRINTS
 PR00339; PCNACYCLIN.