UniProt Accession

 HPRT_YEAST; Q04178; D6VT32 

Genbank Protein ID

 U32274; BK006938 

Genbank Nucleotide ID

 AAB64840.1; DAA12242.1 

Protein Name

 Hypoxanthine-guanine phosphoribosyltransferase 

Protein Synonyms/Alias

 HGPRT; HGPRTase; Bypass of repression by adenine protein 6 

Gene Name

 HPT1 

Gene Synonyms/Alias

 BRA6; YDR399W; D9509.18 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
6	**MSANDKQYISYNN	acetylation	[1]
29	AERIKNFKPDLIIAI	ubiquitination	[2]
52	RILRTFLKEPGVPTI	acetylation	[1]
143	AKGIDTEKSPEMKTN	ubiquitination	[3]
182	KNRYFAAKTVPDKWY	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. 

Sequence Annotation

 NP_BIND 110 118 GMP.
 NP_BIND 188 194 GMP.
 ACT_SITE 114 114 Proton acceptor (By similarity).
 BINDING 85 85 GMP.
 BINDING 159 159 GMP.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Glycosyltransferase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0052657; F:guanine phosphoribosyltransferase activity; IEA:EC.
 GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0032263; P:GMP salvage; IDA:SGD.
 GO:0032264; P:IMP salvage; IDA:SGD.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. 

Interpro

 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS