CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016769
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial inner membrane protein 
Protein Synonyms/Alias
 Mitofilin 
Gene Name
 Immt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
257NSEIAGEKKSAQWRTacetylation[1]
257NSEIAGEKKSAQWRTubiquitination[2]
270RTVEGALKERRKAVDacetylation[1]
287ADALLKAKEELEKMKacetylation[1]
415AQQKATEKQHIELALacetylation[1]
424HIELALEKHKLEEKRacetylation[1]
426ELALEKHKLEEKRTFacetylation[1]
494KVQEQELKYEFEQGLacetylation[1]
504FEQGLSEKLSEQELEubiquitination[2]
663LFPPKQLKPPAELYPacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 MOD_RES 210 210 N6-acetyllysine (By similarity).
 MOD_RES 221 221 N6-acetyllysine (By similarity).
 MOD_RES 450 450 N6-acetyllysine (By similarity).
 MOD_RES 505 505 N6-acetyllysine.
 MOD_RES 506 506 Phosphotyrosine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MLRACQLSGV TVAAQSCLCG KFVLRPLRPC RRYSTSSSSG LTAGKIAGAG LLFVGGGIGG 60
TILYAKWDSH FRESVEKTIP YSDKLFGMVL GSAPYTVPLP KKPVQSGPLK ISSVSEVMKD 120
SKLPVAQSQK TKGDTPASAA GDTLSVPAPA VQHEDTIKTE CPNTNEGKST SETTEEAFSS 180
SVRERPPEEV AARLAQQEKQ EQVEMESLAK SLEDALNRTS SVTLQTITAQ NAAVQAVKAH 240
SNILKTAMDN SEIAGEKKSA QWRTVEGALK ERRKAVDEAA DALLKAKEEL EKMKTIIEDA 300
KKREIAGATP HITAAEGRLH NMIVDLDNVV KKVQAAQSEA KVVSQYHELV VQARDDFRKE 360
LDSITPDITP GWKGMSISDL AGKLSTDDLN SLIAHAHRRI DQLNRELAQQ KATEKQHIEL 420
ALEKHKLEEK RTFDSAVAKA LEHHRSEIQA EQDRKVEEVR DAMENEMRTQ LRRQAAAHTD 480
HLRDVLKVQE QELKYEFEQG LSEKLSEQEL EFRRRSQEQM DSFTLDINTA YARLRGIEQA 540
VQSHAVAEEE ARKAHQLWLS VEALKYSMKT SSAEMPTIPL GSAVEAIRVN CSDNEFTQAL 600
TAAIPPESLT RGVYSEETLR ARFYAVQKLA RRVAMIDETR NSLYQYFLSY LQSLLLFPPK 660
QLKPPAELYP EDINTFKLLS YASYCIEHGD LELAAKFVNQ LKGESRRVAQ DWLKEARMTL 720
ETKQIVEILT AYASAVGIGT TQVQQE 746 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:MGI.
 GO:0009409; P:response to cold; IEA:Compara. 
Interpro
 IPR019133; Mt-IM_prot_Mitofilin. 
Pfam
 PF09731; Mitofilin 
SMART
  
PROSITE
  
PRINTS