UniProt Accession

 LMNB2_MOUSE; P21619; P48680; Q8CGB1 

Genbank Protein ID

 X54098; D13455; BC042430; BC051985 

Genbank Nucleotide ID

 CAA38032.1; BAA02708.1; AAH42430.1; AAH51985.1 

Protein Name

 Lamin-B2 

Protein Synonyms/Alias

  

Gene Name

 Lmnb2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	LLLRISEKEEVTTRE	ubiquitination	[1]
101	RLQIEIGKVQAELEE	ubiquitination	[1]
115	EARKSAKKREGELTV	ubiquitination	[1]
128	TVAQGRVKDLESLFH	ubiquitination	[1]
148	LATALSDKQGLETEV	ubiquitination	[1]
164	ELRAQLAKAEDGHAV	ubiquitination	[1]
173	EDGHAVAKKQLEKET	acetylation	[2]
233	RQQEYDFKMAQALED	ubiquitination	[1]
263	LEQTYQAKLDNAKLL	ubiquitination	[1]
268	QAKLDNAKLLSDQND	ubiquitination	[1]
276	LLSDQNDKAAHAARE	ubiquitination	[1]
329	GERDKFRKMLDAKEQ	ubiquitination	[1]
470	RLKNSSDKDQSLGNW	ubiquitination	[1]
496	IAYKFTPKYVLRAGQ	ubiquitination	[1]
551	DGEEVAVKAAKHSSV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. 

Sequence Annotation

 REGION 1 26 Head.
 REGION 27 378 Rod.
 REGION 27 61 Coil 1A.
 REGION 62 73 Linker 1.
 REGION 74 207 Coil 1B.
 REGION 208 234 Linker 2.
 REGION 235 378 Coil 2.
 REGION 379 596 Tail.
 MOTIF 415 420 Nuclear localization signal (Potential).
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 15 15 Phosphoserine (By similarity).
 MOD_RES 59 59 N6-acetyllysine (By similarity).
 MOD_RES 398 398 Phosphoserine (By similarity).
 MOD_RES 400 400 Phosphoserine (By similarity).
 MOD_RES 427 427 Phosphoserine.
 MOD_RES 494 494 Phosphothreonine.
 MOD_RES 593 593 Cysteine methyl ester (By similarity).
 LIPID 593 593 S-farnesyl cysteine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Lipoprotein; Membrane; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 596 AA 

Protein Sequence

Gene Ontology

 GO:0005638; C:lamin filament; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 

Pfam

 PF00038; Filament
 PF00932; LTD 

SMART

  

PROSITE

 PS00226; IF 

PRINTS