CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GAS2-like protein 1 
Protein Synonyms/Alias
 GAS2-related protein on chromosome 22; Growth arrest-specific protein 2-like 1 
Gene Name
 GAS2L1 
Gene Synonyms/Alias
 GAR22 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14GIAGSAAKSVRPFRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Seems to be involved in the cross-linking of microtubules and microfilaments. 
Sequence Annotation
 DOMAIN 27 147 CH.
 DOMAIN 203 275 GAR.
 MOD_RES 193 193 Phosphothreonine.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 391 391 Phosphothreonine.
 MOD_RES 394 394 Phosphoserine.
 MOD_RES 492 492 Phosphoserine.
 MOD_RES 498 498 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 681 AA 
Protein Sequence
MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD GFLTGLATGT 60
TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR DNVATFIGWC RVELGVPEVL 120
MFETEDLVLR KNEKSVVLCL LEVARRGARL GLLAPRLVQF EQEIERELRA APPAPNAPAA 180
GEDTTETAPA PGTPARGPRM TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS 240
SLLIFVRVLR SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT 300
SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR YSGDSDSSAS 360
SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA LRSQSRDRLD RGRPRGAPGG 420
RGAQLSVPSP ARRARSQSRE EQAVLLVRRD RDGQHSWVPR GRGSGGSGRS TPQTPRARSP 480
AAPRLSRVSS PSPELGTTPA SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP 540
TGPVPDPARA PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS 600
SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP RGPRRPSGPA 660
ELGTWHALHS VTPRAEPDSW M 681 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0008093; F:cytoskeletal adaptor activity; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0046966; F:thyroid hormone receptor binding; IDA:UniProtKB.
 GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
 GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:UniProtKB.
 GO:0001578; P:microtubule bundle formation; IMP:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IDA:UniProtKB.
 GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
 GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB.
 GO:0051726; P:regulation of cell cycle; IDA:UniProtKB. 
Interpro
 IPR001715; CH-domain.
 IPR003108; GAS2_dom. 
Pfam
 PF00307; CH
 PF02187; GAS2 
SMART
 SM00033; CH
 SM00243; GAS2 
PROSITE
 PS50021; CH
 PS51460; GAR 
PRINTS