CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004571
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar transcription factor 1 
Protein Synonyms/Alias
 Autoantigen NOR-90; Upstream-binding factor 1; UBF-1 
Gene Name
 UBTF 
Gene Synonyms/Alias
 UBF; UBF1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71SGDMCKLKWVEISNEubiquitination[1]
132EKRAKYAKLHPEMSNubiquitination[1]
216HEKKVYLKVRPDEIMubiquitination[1]
229IMRDYIQKHPELNISubiquitination[1]
242ISEEGITKSTLTKAEubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. 
Sequence Annotation
 DNA_BIND 112 180 HMG box 1.
 DNA_BIND 196 264 HMG box 2.
 DNA_BIND 298 362 HMG box 3.
 DNA_BIND 407 475 HMG box 4.
 DNA_BIND 482 549 HMG box 5.
 DNA_BIND 568 634 HMG box 6.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 201 201 Phosphothreonine.
 MOD_RES 273 273 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 364 364 Phosphoserine (By similarity).
 MOD_RES 389 389 Phosphoserine (By similarity).
 MOD_RES 412 412 Phosphoserine.
 MOD_RES 433 433 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 495 495 Phosphoserine.
 MOD_RES 546 546 Phosphoserine (By similarity).
 MOD_RES 584 584 Phosphoserine (By similarity).
 MOD_RES 638 638 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 764 AA 
Protein Sequence
MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF 60
KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF 120
RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR 180
EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD EIMRDYIQKH PELNISEEGI 240
TKSTLTKAER QLKDKFDGRP TKPPPNSYSL YCAELMANMK DVPSTERMVL CSQQWKLLSQ 300
KEKDAYHKKC DQKKKDYEVE LLRFLESLPE EEQQRVLGEE KMLNINKKQA TSPASKKPAQ 360
EGGKGGSEKP KRPVSAMFIF SEEKRRQLQE ERPELSESEL TRLLARMWND LSEKKKAKYK 420
AREAALKAQS ERKPGGEREE RGKLPESPKR AEEIWQQSVI GDYLARFKND RVKALKAMEM 480
TWNNMEKKEK LMWIKKAAED QKRYERELSE MRAPPAATNS SKKMKFQGEP KKPPMNGYQK 540
FSQELLSNGE LNHLPLKERM VEIGSRWQRI SQSQKEHYKK LAEEQQKQYK VHLDLWVKSL 600
SPQDRAAYKE YISNKRKSMT KLRGPNPKSS RTTLQSKSES EEDDEEDEDD EDEDEEEEDD 660
ENGDSSEDGG DSSESSSEDE SEDGDENEED DEDEDDDEDD DEDEDNESEG SSSSSSSSGD 720
SSDSDSN 727 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0001832; P:blastocyst growth; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; ISS:UniProtKB.
 GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome. 
Interpro
 IPR009071; HMG_box_dom. 
Pfam
 PF09011; DUF1898
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS