CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 PH domain leucine-rich repeat-containing protein phosphatase 2 
Protein Synonyms/Alias
  
Gene Name
 PHLPP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
627LPDTLFSKALNLRYLubiquitination[1]
726PTTIANCKRLHTLVAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1358 AA 
Protein Sequence
MGEVEPGPAG PLEPPEPPEA PASRRPGGIR VLKRNMKRNG SRNCLNRRSR FGSRERDWLR 60
EDVKRGCVYL YGADTTTATT TTTTSSSSSS SSSSSDLHLV LCTVETPASE ICAGEGRESL 120
YLQLHGDLVR RLEPTERPLQ IVYDYLSRLG FDDPVRIQEE ATNPDLGCMI RFYGEKPCHM 180
DRLDRILLSG IYNVRKGKTQ LHKWAERLVV LCGTCLIVSS VKDCQTGKMH ILPLVGGKIE 240
EVKRRQYSLA FSSAGAQAQT YHVSFETLAE YQRWQRQASK VVSQRISTVD LSCYSLEEVP 300
EHLFYSQDIT YLNLRHNFMQ LERPGGLDTL YKFSQLKGLN LSHNKLGLFP ILLCEISTLT 360
ELNLSCNGFH DLPSQIGNLL NLQTLCLDGN FLTTLPEELG NLQQLSSLGI SFNNFSQIPE 420
VYEKLTMLDR VVMAGNCLEV LNLGVLNRMN HIKHVDLRMN HLKTMVIENL EGNKHITHVD 480
LRDNRLTDLD LSSLCSLEQL HCGRNQLREL TLSGFSLRTL YASSNRLTAV NVYPVPSLLT 540
FLDLSRNLLE CVPDWACEAK KIEVLDVSYN LLTEVPVRIL SSLSLRKLML GHNHVQNLPT 600
LVEHIPLEVL DLQHNALTRL PDTLFSKALN LRYLNASANS LESLPSACTG EESLSMLQLL 660
YLTNNLLTDQ CIPVLVGHLH LRILHLANNQ LQTFPASKLN KLEQLEELNL SGNKLKTIPT 720
TIANCKRLHT LVAHSNNISI FPEILQLPQI QFVDLSCNDL TEILIPEALP ATLQDLDLTG 780
NTNLVLEHKT LDIFSHITTL KIDQKPLPTT DSTVTSTFWS HGLAEMAGQR NKLCVSALAM 840
DSFAEGVGAV YGMFDGDRNE ELPRLLQCTM ADVLLEEVQQ STNDTVFMAN TFLVSHRKLG 900
MAGQKLGSSA LLCYIRPDTA DPASSFSLTV ANVGTCQAVL CRGGKPVPLS KVFSLEQDPE 960
EAQRVKDQKA IITEDNKVNG VTCCTRMLGC TYLYPWILPK PHISSTPLTI QDELLILGNK 1020
ALWEHLSYTE AVNAVRHVQD PLAAAKKLCT LAQSYGCQDN VGAMVVYLNI GEEGCTCEMN 1080
GLTLPGPVGF ASTTTIKDAP KPATPSSSSG IASEFSSEMS TSEVSSEVGS TASDEHNAGG 1140
LDTALLPRPE RRCSLHPTPT SGLFQRQPSS ATFSSNQSDN GLDSDDDQPV EGVITNGSKV 1200
EVEVDIHCCR GRDLENSPPL IESSPTLCSE EHARGSCFGI RRQNSVNSGM LLPMSKDRME 1260
LQKSPSTSCL YGKKLSNGSI VPLEDSLNLI EVATEVPKRK TGYFAAPTQM EPEDQFVVPH 1320
DLEEEVKEQM KQHQDSRLEP EPHEEDRTEP PEEFDTAL 1358 
Gene Ontology
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR001932; PP2C-like. 
Pfam
 PF00560; LRR_1
 PF00481; PP2C 
SMART
 SM00369; LRR_TYP
 SM00332; PP2Cc 
PROSITE
 PS51450; LRR 
PRINTS