CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Geranylgeranyl pyrophosphate synthase 
Protein Synonyms/Alias
  
Gene Name
 GGPS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3*****MEKTQETVQRubiquitination[1, 2, 3]
17RILLEPYKYLLQLPGubiquitination[2, 4]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isoprene biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 230 AA 
Protein Sequence
MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 60
LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 120
ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL 180
GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV 230 
Gene Ontology
 GO:0004337; F:geranyltranstransferase activity; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR000092; Polyprenyl_synt.
 IPR017446; Polyprenyl_synth-rel.
 IPR008949; Terpenoid_synth. 
Pfam
 PF00348; polyprenyl_synt 
SMART
  
PROSITE
 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 
PRINTS