CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037135
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ankyrin repeat domain-containing protein 17 
Protein Synonyms/Alias
  
Gene Name
 ANKRD17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
73LEAAGIGKLSTADGKubiquitination[1]
80KLSTADGKAFADPEVubiquitination[1, 2]
523GGRTPLMKAARAGHVubiquitination[1]
582ADPTHRLKDGSTMLIubiquitination[1]
1037EAQSERTKDTPLSLAubiquitination[1]
1170ANVEHRAKTGLTPLMubiquitination[1]
1217ALTIAADKGHYKFCEubiquitination[1, 2, 3]
1221AADKGHYKFCELLIGubiquitination[1]
1608QKREEGWKEVVRRSKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2490 AA 
Protein Sequence
MVETAAEMEA YVLEDILEVE SFILDQDDLE NPMLETASKL LLSGTADGAD LRTVDPETQA 60
RLEALLEAAG IGKLSTADGK AFADPEVLRR LTSSVSCALD EAAAALTRMR AESTANAGQS 120
DNRSLAEACS EGDVNAVRKL LIEGRSVNEH TEEGESLLCL ACSAGYYELA QVLLAMHANV 180
EDRGIKGDIT PLMAAANGGH VKIVKLLLAH KADVNAQSST GNTALTYACA GGYVDVVKVL 240
LESGASIEDH NENGHTPLME AGSAGHVEVA RLLLENGAGI NTHSNEFKES ALTLACYKGH 300
LEMVRFLLEA GADQEHKTDE MHTALMEACM DGHVEVARLL LDSGAQVNMP ADSFESPLTL 360
AACGGHVELA ALLIERGASL EEVNDEGYTP LMEAAREGHE EMVALLLGQG ANINAQTEET 420
QETALTLACC GGFLEVADFL IKAGADIELG CSTPLMEAAQ EGHLELVKYL LAAGANVHAT 480
TATGDTALTY ACENGHTDVA DVLLQAGADL EHESEGGRTP LMKAARAGHV CTVQFLISKG 540
ANVNRTTANN DHTVLSLACA GGHLAVVELL LAHGADPTHR LKDGSTMLIE AAKGGHTSVV 600
CYLLDYPNNL LSAPPPDVTQ LTPPSHDLNR APRVPVQALP MVVPPQEPDK PPANVATTLP 660
IRNKAASKQK SSSHLPANSQ DVQGYITNQS PESIVEEAQG KLTELEQRIK EAIEKNAQLQ 720
SLELAHADQL TKEKIEELNK TREEQIQKKQ KILEELQKVE RELQLKTQQQ LKKQYLEVKA 780
QRIQLQQQQQ QSCQHLGLLT PVGVGEQLSE GDYARLQQVD PVLLKDEPQQ TAAQMGFAPI 840
QPLAMPQALP LAAGPLPPGS IANLTELQGV IVGQPVLGQA QLAGLGQGIL TETQQGLMVA 900
SPAQTLNDTL DDIMAAVSGR ASAMSNTPTH SIAASISQPQ TPTPSPIISP SAMLPIYPAI 960
DIDAQTESNH DTALTLACAG GHEELVQTLL ERGASIEHRD KKGFTPLILA ATAGHVGVVE 1020
ILLDNGADIE AQSERTKDTP LSLACSGGRQ EVVELLLARG ANKEHRNVSD YTPLSLAASG 1080
GYVNIIKILL NAGAEINSRT GSKLGISPLM LAAMNGHTAA VKLLLDMGSD INAQIETNRN 1140
TALTLACFQG RTEVVSLLLD RKANVEHRAK TGLTPLMEAA SGGYAEVGRV LLDKGADVNA 1200
PPVPSSRDTA LTIAADKGHY KFCELLIGRG AHIDVRNKKG NTPLWLAANG GHLDVVQLLV 1260
QAGADVDAAD NRKITPLMAA FRKGHVKVVR YLVKEVNQFP SDSECMRYIA TITDKEMLKK 1320
CHLCMESIVQ AKDRQAAEAN KNASILLEEL DLEKLREESR RLALAAKREK RKEKRRKKKE 1380
EQRRKLEEIE AKNKENFELQ AAQEKEKLKV EDEPEVLTEP PSATTTTTIG ISATWTTLAG 1440
SHGKRNNTIT TTSSKRKNRK NKITPENVQI IFDDPLPISY SQPEKVNGES KSSSTSESGD 1500
SDNMRISSCS DESSNSNSSR KSDNHSPAVV TTTVSSKKQP SVLVTFPKEE RKSVSGKASI 1560
KLSETISEGT SNSLSTCTKS GPSPLSSPNG KLTVASPKRG QKREEGWKEV VRRSKKVSVP 1620
STVISRVIGR GGCNINAIRE FTGAHIDIDK QKDKTGDRII TIRGGTESTR QATQLINALI 1680
KDPDKEIDEL IPKNRLKSSS ANSKIGSSAP TTTAANTSLM GIKMTTVALS STSQTATALT 1740
VPAISSASTH KTIKNPVNNV RPGFPVSLPL AYPPPQFAHA LLAAQTFQQI RPPRLPMTHF 1800
GGTFPPAQST WGPFPVRPLS PARATNSPKP HMVPRHSNQN SSGSQVNSAG SLTSSPTTTT 1860
SSSASTVPGT STNGSPSSPS VRRQLFVTVV KTSNATTTTV TTTASNNNTA PTNATYPMPT 1920
AKEHYPVSSP SSPSPPAQPG GVSRNSPLDC GSASPNKVAS SSEQEAGSPP VVETTNTRPP 1980
NSSSSSGSSS AHSNQQQPPG SVSQEPRPPL QQSQVPPPEV RMTVPPLATS SAPVAVPSTA 2040
PVTYPMPQTP MGCPQPTPKM ETPAIRPPPH GTTAPHKNSA SVQNSSVAVL SVNHIKRPHS 2100
VPSSVQLPST LSTQSACQNS VHPANKPIAP NFSAPLPFGP FSTLFENSPT SAHAFWGGSV 2160
VSSQSTPESM LSGKSSYLPN SDPLHQSDTS KAPGFRPPLQ RPAPSPSGIV NMDSPYGSVT 2220
PSSTHLGNFA SNISGGQMYG PGAPLGGAPA AANFNRQHFS PLSLLTPCSS ASNDSSAQSV 2280
SSGVRAPSPA PSSVPLGSEK PSNVSQDRKV PVPIGTERSA RIRQTGTSAP SVIGSNLSTS 2340
VGHSGIWSFE GIGGNQDKVD WCNPGMGNPM IHRPMSDPGV FSQHQAMERD STGIVTPSGT 2400
FHQHVPAGYM DFPKVGGMPF SVYGNAMIPP VAPIPDGAGG PIFNGPHAAD PSWNSLIKMV 2460
SSSTENNGPQ TVWTGPWAPH MNSVHMNQLG 2490 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF00013; KH_1 
SMART
 SM00248; ANK
 SM00322; KH 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50084; KH_TYPE_1 
PRINTS
 PR01415; ANKYRIN.