UniProt Accession

 ACSL4_HUMAN; O60488; D3DUY2; O60848; O60849 

Genbank Protein ID

 AF030555; Y12777; Y13058; CH471120; CH471120; BC034959 

Genbank Nucleotide ID

 AAC17493.1; CAA73314.1; CAA73501.1; EAX02671.1; EAX02673.1; AAH34959.1 

Protein Name

 Long-chain-fatty-acid--CoA ligase 4 

Protein Synonyms/Alias

 Long-chain acyl-CoA synthetase 4; LACS 4 

Gene Name

 ACSL4 

Gene Synonyms/Alias

 ACS4; FACL4; LACS4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	LFDHAVSKFGKKDSL	ubiquitination	[1]
72	NEMQPNGKVFKKLIL	ubiquitination	[1]
83	KLILGNYKWMNYLEV	ubiquitination	[1]
107	GLTALGLKPKNTIAI	ubiquitination	[1]
190	HIIYVDNKAINKAEY	ubiquitination	[1]
313	TLSDQSSKIKKGSKG	ubiquitination	[1]
342	EIMDRIYKNVMSKVQ	ubiquitination	[1]
347	IYKNVMSKVQEMNYI	ubiquitination	[1]
360	YIQKTLFKIGYDYKL	ubiquitination	[1]
459	ICCEIKLKDWQEGGY	ubiquitination	[1]
495	GYFKNEEKTAEDYSV	ubiquitination	[1]
546	GEYVSLGKVEAALKN	ubiquitination	[1]
580	SFVVPNQKRLTLLAQ	ubiquitination	[1]
610	AMEAEILKEIREAAN	ubiquitination	[1]
620	REAANAMKLERFEIP	ubiquitination	[1]
629	ERFEIPIKVRLSPEP	ubiquitination	[1]
649	GLVTDAFKLKRKELR	ubiquitination	[1]
661	ELRNHYLKDIERMYG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. 

Sequence Annotation

  

Keyword

 Alport syndrome; Alternative splicing; ATP-binding; Complete proteome; Deafness; Disease mutation; Elliptocytosis; Endoplasmic reticulum; Fatty acid metabolism; Hereditary hemolytic anemia; Ligase; Lipid metabolism; Magnesium; Membrane; Mental retardation; Microsome; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Peroxisome; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 711 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0047676; F:arachidonate-CoA ligase activity; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IDA:MGI.
 GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IMP:UniProtKB.
 GO:0060996; P:dendritic spine development; IEA:Compara.
 GO:0060136; P:embryonic process involved in female pregnancy; IEA:Compara.
 GO:0015908; P:fatty acid transport; IEA:Compara.
 GO:0008610; P:lipid biosynthetic process; IDA:UniProtKB.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0032307; P:negative regulation of prostaglandin secretion; IDA:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.
 GO:0070672; P:response to interleukin-15; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 

Pfam

 PF00501; AMP-binding 

SMART

  

PROSITE

 PS00455; AMP_BINDING 

PRINTS