CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020853
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S9, mitochondrial 
Protein Synonyms/Alias
 MRP-S9; S9mt 
Gene Name
 Mrps9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75SYTEDFIKKQIEEFNacetylation[1]
174GKVMQLEKHRGPLSAacetylation[1, 2, 3, 4, 5, 6]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
 MOD_RES 174 174 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MAAPCVSCGR VLSLWFTPAV RASLCQRPGY WTASAVGWQT GTRFQLSKLI HTTVVTTKKN 60
VQASRQESYT EDFIKKQIEE FNIGKRHLAN MMGEDPETFA EEDIDRAIAY LFPSGLFEKR 120
ARPMMKHPEH IFPKQRATQW GEDGRPFHFL FYTGKQSYYS LMHDVYGKVM QLEKHRGPLS 180
ASAESRDLIG SRWLIKEELE EMLVEKLSDE DYAQFIRLLE KLLTLPCGPA EEEFVQRFRR 240
SVTIQSKKQL IEPVQYDEQG MAFSTSEGRR KSATAQAVVY EHGSGKIHVN GVDYLIYFPI 300
TQDREQLMFP FHFLDRLERH DVTCTVSGGG RSAQAGAIRL AMARALCSFV TEDEVEWMRQ 360
AGLLTPDPRI RERKKPGQEG ARRKFTWKKR 390 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR000754; Ribosomal_S9.
 IPR020574; Ribosomal_S9_CS. 
Pfam
 PF00380; Ribosomal_S9 
SMART
  
PROSITE
 PS00360; RIBOSOMAL_S9 
PRINTS