CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013571
UniProt Accession
Genbank Protein ID
 AY542354; AY542328; AY542329; AY542331; AY542330; AY542332; AY542334; AY542336; AY542338; AY542340; AY542349; AY542348; AY542347; AY542346; AY542345; AY542344; AY542343; AY542342; AY542341; AY542353; AY542352; AY542351; AY542350; AY542339; AY542337; AY542335; AY542333; AY542354; AY542328; AY542329; AY542330; AY542332; AY542335; AY542334; AY542333; AY542331; AY542336; AY542345; AY542344; AY542343; AY542342; AY542341; AY542340; AY542339; AY542338; AY542337; AY542353; AY542352; AY542351; AY542350; AY542349; AY542347; AY542354; AY542328; AY542329; AY542331; AY542332; AY542330; AY542333; AY542335; AY542337; AY542340; AY542349; AY542348; AY542347; AY542345; AY542338; AY542344; AY542343; AY542342; AY542341; AY542353; AY542352; AY542351; AY542350; AY542339; AY542336; AY542334; AY542354; AY542329; AY542330; AY542328; AY542331; AY542333; AY542335; AY542337; AY542346; AY542345; AY542344; AY542343; AY542342; AY542341; AY542340; AY542339; AY542338; AY542353; AY542352; AY542351; AY542350; AY542349; AY542347; AY542336; AY542334; AY542332; AY542324; AY542325; AY542326; AY542327; AK035159; AK137325; AK161955 
Genbank Nucleotide ID
 AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68171.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68172.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68173.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68174.1; AAT68175.1; AAT68176.1; AAT68177.1; AAT68178.1; BAC28964.1; BAE23307.1; BAE36652.1 
Protein Name
 Syntaxin-binding protein 5-like 
Protein Synonyms/Alias
 Lethal(2) giant larvae protein homolog 4; Tomosyn-2 
Gene Name
 Stxbp5l 
Gene Synonyms/Alias
 Llgl4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
926NNTDENEKTWKRKLVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in vesicle trafficking and exocytosis (Potential). 
Sequence Annotation
 REPEAT 73 106 WD 1.
 REPEAT 113 152 WD 2.
 REPEAT 157 193 WD 3.
 REPEAT 212 246 WD 4.
 REPEAT 252 284 WD 5.
 REPEAT 306 348 WD 6.
 REPEAT 356 390 WD 7.
 REPEAT 412 489 WD 8.
 REPEAT 517 628 WD 9.
 REPEAT 642 704 WD 10.
 REPEAT 831 888 WD 11.
 REPEAT 897 968 WD 12.
 REPEAT 973 1017 WD 13.
 REPEAT 1031 1054 WD 14.
 DOMAIN 1120 1180 v-SNARE coiled-coil homology.
 MOD_RES 588 588 Phosphoserine.
 MOD_RES 590 590 Phosphoserine.
 MOD_RES 593 593 Phosphothreonine.
 MOD_RES 598 598 Phosphoserine.  
Keyword
 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Exocytosis; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1185 AA 
Protein Sequence
MKKFNFRKVL DGLTASSPGS GSSSGSNSGG AGSGSVHPGG TAGLPREEIQ ESLTSDYFQI 60
CKTVRHGFPY QPTALAFDPV QKILAIGTRT GAIRILGRPG VDCYCQHESG AAVLQLQFLI 120
NEGALVSASS DDTLHLWNLR QKRPAILHSL KFNRERITYC HLPFQSKWLY VGTERGNTHI 180
VNIESFILSG YVIMWNKAIE LSTKTHPGPV VHLSDSPRDE GKLLIGYENG TVVFWDLKSK 240
RAELRVYYDE AIHSIDWHHE GKQFMCSHSD GSLTLWNLKS PSRPFQTTVP HGKSQREGRK 300
SESCKPILKV EYKTCRNSEP FIIFSGGLSY DKACRRPSLT IMHGKAITVL EMDHPIVEFL 360
TLCETPYPNE FQEPYAVAVL LEKDLIVVDL TQTNFPIFEN PYPMDIHESP VTCTAYFADC 420
PPDLILVLYS IGVKHKKQGY SNKEWPVSGG AWNLGAQTYP EIIITGHADG TIKFWDASAM 480
TLQMLYKLKT SKVFEKQKAG EGKQTCELVE EDPFAVQMIY WCPESRIFCV SGVSAYVIIY 540
KFSRHEVTTE IVSLEVRLQC DVEDIITPEP ETSPPFPDLS SQLPPSRSLS GSTNTVSSEG 600
VTKDSIPCLS VKTRPVRMPP GYQADLVIQL VWVDGEPPQQ ITSLSISSAY GIVAFGNCTG 660
LVVVDFIQKT VLLSMGTIDL YRSSDLYQRQ PRSPRKNRQF IADNFCMRGL SNFYPDLTKR 720
IRTSYQSLTE LNDSPVPLEL ERCKSPTSDH VNGHCTSPTS QSCSSGKRLS SADVSKVNRW 780
GPGRPPFRKA QSAACMEISL PVTTEETREN SYNRSRSSSI SSIDKDSKEA ITALYFMESF 840
ARKNDSTVSP CLFVGTSLGM VVLISLNLPS SDEQRFTEPV VVLPSGTFLS LKGAVLTFSC 900
MDRTGSLMQP PYEVWRDPNN TDENEKTWKR KLVMNYSSSS QEMGDHQYTI ICSEKQAKVF 960
SLPSQTCLYV HNITETSFIL QADVVVMCNS ACLACFCANG HIMIMSLPSL RPMLDVNYLP 1020
LTDMRIARTF CFTNEGQALY LVSPTEIQRL TYSQEMCDNI QDMLGDLFTP IETPEAQNRG 1080
FLKGLFGGSG QTFDREELFG EASAGKASRS LAQHIPGPGS IEGMKGAAGG VMGELTRARI 1140
ALDERGQRLG ELEEKTAGMM TSAEAFSKHA HELMLKYKDK KWYQF 1185 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0019905; F:syntaxin binding; IDA:MGI.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0046676; P:negative regulation of insulin secretion; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0017157; P:regulation of exocytosis; IDA:MGI. 
Interpro
 IPR000664; Lethal2_giant.
 IPR013905; Lgl_C.
 IPR013577; LLGL2.
 IPR001388; Synaptobrevin.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08596; Lgl_C
 PF08366; LLGL
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50892; V_SNARE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00962; LETHAL2GIANT.