UniProt Accession

 STYL1_HUMAN; Q9Y6J8; Q9UBP1; Q9UK06; Q9UK07; Q9UKG2; Q9UKG3 

Genbank Protein ID

 AF069762; AC006330; BC024035; AF188201; AF188202; AF188203; AF188204; AF169647; AF169648 

Genbank Nucleotide ID

 AAD36983.1; AAS07535.1; AAH24035.1; AAF04111.1; AAF04112.1; AAF04113.1; AAF04114.1; AAD53723.1; AAD53724.1 

Protein Name

 Serine/threonine/tyrosine-interacting-like protein 1 

Protein Synonyms/Alias

 Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; Map kinase phosphatase-like protein MK-STYX 

Gene Name

 STYXL1 

Gene Synonyms/Alias

 DUSP24; MKSTYX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	CLLDVRSKWEYDESH	ubiquitination	[1]
128	HHPVYILKGGYERFS	ubiquitination	[1]
145	YHFLRTQKIIWMPQE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. 

Sequence Annotation

 DOMAIN 17 140 Rhodanese.
 DOMAIN 160 301 Tyrosine-protein phosphatase.  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR001763; Rhodanese-like_dom. 

Pfam

 PF00782; DSPc
 PF00581; Rhodanese 

SMART

 SM00195; DSPc
 SM00450; RHOD 

PROSITE

 PS50206; RHODANESE_3
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS