UniProt Accession

 VAPB_RAT; Q9Z269 

Genbank Protein ID

 AF086631; BC065576 

Genbank Nucleotide ID

 AAD13580.1; AAH65576.1 

Protein Name

 Vesicle-associated membrane protein-associated protein B 

Protein Synonyms/Alias

 VAMP-B; VAMP-associated protein B; VAP-B 

Gene Name

 Vapb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKVEQVLSL	acetylation	[1]
118	PEDLMDSKLRCVFEL	acetylation	[1]
191	REESRQLKEEDGLRA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (By similarity). Involved in cellular calcium homeostasis regulation (By similarity). 

Sequence Annotation

 DOMAIN 7 124 MSP.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
 GO:0019899; F:enzyme binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; ISS:UniProtKB.
 GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
 GO:0045070; P:positive regulation of viral genome replication; ISS:UniProtKB.
 GO:0019048; P:virus-host interaction; ISS:UniProtKB. 

Interpro

 IPR000535; Major_sperm.
 IPR008962; PapD-like.
 IPR016763; Vesicle-associated_membrane. 

Pfam

 PF00635; Motile_Sperm 

SMART

  

PROSITE

 PS50202; MSP 

PRINTS