UniProt Accession

 CD166_HUMAN; Q13740; B2RNS3; B4DTU0; O60892; Q1HGM8; Q1HGM9 

Genbank Protein ID

 L38608; DQ486139; DQ486140; AK300362; AK316113; AC023602; AC078806; AC133476; BC137096; BC137097; Y10183 

Genbank Nucleotide ID

 AAB59499.1; ABF48405.1; ABF48406.1; BAG62102.1; BAH14484.1; AAI37097.1; AAI37098.1; CAA71256.1 

Protein Name

 CD166 antigen 

Protein Synonyms/Alias

 Activated leukocyte cell adhesion molecule; CD166 

Gene Name

 ALCAM 

Gene Synonyms/Alias

 MEMD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	YDDVPEYKDRLNLSE	ubiquitination	[1]
563	TASKHVNKDLGNMEE	ubiquitination	[2]
572	LGNMEENKKLEENNH	ubiquitination	[1]
573	GNMEENKKLEENNHK	ubiquitination	[1]
580	KLEENNHKTEA****	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 

Sequence Annotation

 DOMAIN 28 120 Ig-like V-type 1.
 DOMAIN 125 234 Ig-like V-type 2.
 DOMAIN 245 328 Ig-like C2-type 1.
 DOMAIN 333 409 Ig-like C2-type 2.
 DOMAIN 416 501 Ig-like C2-type 3.
 CARBOHYD 91 91 N-linked (GlcNAc...).
 CARBOHYD 95 95 N-linked (GlcNAc...).
 CARBOHYD 167 167 N-linked (GlcNAc...).
 CARBOHYD 265 265 N-linked (GlcNAc...).
 CARBOHYD 306 306 N-linked (GlcNAc...) (Potential).
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...).
 CARBOHYD 466 466 N-linked (GlcNAc...); atypical.
 CARBOHYD 480 480 N-linked (GlcNAc...).
 CARBOHYD 499 499 N-linked (GlcNAc...).
 DISULFID 43 113 Potential.
 DISULFID 157 220 Potential.
 DISULFID 270 313 Potential.
 DISULFID 354 392 Potential.
 DISULFID 435 485 Potential.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 583 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0008045; P:motor neuron axon guidance; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS