| Tag | Content |
|---|
| CPLM ID | CPLM-011755 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Telomere length regulation protein ELG1 |
Protein Synonyms/Alias | Regulator of Ty1 transposition protein 110; Telomere elongation suppressor ELG1 |
Gene Name | ELG1 |
Gene Synonyms/Alias | RTT110; YOR144C; O3510; YOR3510C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 779 | DPSIVVRKWEHLHSG | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re- start, recombination and repair. |
Sequence Annotation | MOD_RES 6 6 Phosphoserine. |
Keyword | Cell cycle; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Telomere. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 791 AA |
Protein Sequence | MKRHVSLSDI LTGNKRKVRR QDALQITIDD ENDTESGTFD ARTAKHDDSS VIFLNHSVVK 60
PIEAVSTNHK SAKEFLMTKR TKEKCDDDDD DLIVISDKSP KSETNCSKIA LSQEHEDDIS 120
IISTSRIKSS LLNERASKIK NFLKHETTDT FKRLNSISKL NEIEPPLPLH QSIFPVGDKE 180
LSDRSVDIPL PFRTIPPLNH NFLPSDYESL KDKNSASCIP VRYQAPVLLG TNIKRNTTLT 240
WPQLFKPVTL KQVLIEPKLK LRIKNWIETS FHTLEKPTLR NRLLNRINPN KQQGSGDELA 300
NFIVPDLEED ENLRPDFYRN GEANSSLSEF VPLMILHGNS IGKKTLIQTI MREIAGDDNS 360
YQIYEVNSNM NRSKKDLLDI LLDFTTTHYV KDSSKRKSDY GLVLFNDVDV LFKEHDRGYW 420
AMISKLCEFS RRPLVLTCKD LSLVPSELIA LASEQNSLFH TKKISTSTVY AFLTKYLKSL 480
EIEVCDDWLR DVVKQNNADI RKCLMHLQFW CVDTEADLIS SKNRLPVLTS TLGSSVKDIS 540
QLTDLLSIND VIGQATLNRS MVRQEIDSTT MTPEKVNTFQ DQNLDDEMKL KFDYVIDYKL 600
HLNDPNRQPL LPFELNIYQH IQEQLEARYS YVREANHRLD NEYLVNRFKK MTESTLNFLA 660
SRIPKYDHLQ SARRTRNSKK ISDILNQFKG IYNDETLNEN AEIDLLSATT QQIKAEINPF 720
VFEIAKSDAN VKNENKQIFE LHSENVSERR YKDLVYQLSQ EGVLKNVWFN ADPSIVVRKW 780
EHLHSGFSKN K 791 |
Gene Ontology | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell. GO:0031391; C:Elg1 RFC-like complex; IPI:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0006261; P:DNA-dependent DNA replication; IMP:SGD. GO:0000724; P:double-strand break repair via homologous recombination; IMP:SGD. GO:0007064; P:mitotic sister chromatid cohesion; IMP:SGD. GO:0045910; P:negative regulation of DNA recombination; NAS:SGD. GO:0010526; P:negative regulation of transposition, RNA-mediated; IMP:SGD. GO:0000723; P:telomere maintenance; TAS:SGD. |
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