CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031365
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BAG family molecular chaperone regulator 2 
Protein Synonyms/Alias
 cDNA FLJ50277, highly similar to BAG family molecular chaperone regulator 2 
Gene Name
 BAG2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121PHGPVDQKFQSIVIGubiquitination[1, 2]
136CALEDQKKIKRRLETubiquitination[2]
153RNIENSDKAIKLLEHacetylation[3]
153RNIENSDKAIKLLEHubiquitination[2, 3, 4, 5]
156ENSDKAIKLLEHSKGubiquitination[2]
162IKLLEHSKGAGSKTLubiquitination[1, 3, 4, 5]
167HSKGAGSKTLQQNAEubiquitination[1, 2, 3, 4, 5, 6, 7]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 178 AA 
Protein Sequence
MPHMWVEALR EAATAVEQEK EILLEMIHSI QNSQDMRQIS DGEREELNLT ANRLMGRTLT 60
VEVSVETIRN PQQQESLKHA TRIIDEVVNK FLDDLGNAKS HLMSLYSACS SEVPHGPVDQ 120
KFQSIVIGCA LEDQKKIKRR LETLLRNIEN SDKAIKLLEH SKGAGSKTLQ QNAESRFN 178 
Gene Ontology
  
Interpro
 IPR003103; BAG_domain. 
Pfam
 PF02179; BAG 
SMART
 SM00264; BAG 
PROSITE
 PS51035; BAG 
PRINTS