UniProt Accession

 B2R5M8_HUMAN; B2R5M8 

Genbank Protein ID

 AK312242 

Genbank Nucleotide ID

 BAG35175.1 

Protein Name

 Isocitrate dehydrogenase [NADP] 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	RLVSGWVKPIIIGRH	ubiquitination	[1]
224	KKYDGRFKDIFQEIY	ubiquitination	[1]
233	IFQEIYDKQYKSQFE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

 NP_BIND 75 77 NADP (By similarity).
 NP_BIND 310 315 NADP (By similarity).
 REGION 94 100 Substrate binding (By similarity).
 METAL 252 252 Magnesium or manganese (By similarity).
 METAL 275 275 Magnesium or manganese (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 82 82 NADP (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 132 132 Substrate (By similarity).
 BINDING 260 260 NADP (By similarity).
 BINDING 328 328 NADP; via amide nitrogen and carbonyl  

Keyword

 Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS