UniProt Accession

 RU17_MOUSE; Q62376; Q3UIW4 

Genbank Protein ID

 AK133115; AK146729; X15769; X15770; X15771; X15772; X15774; X15775; X15776 

Genbank Nucleotide ID

 BAE21515.1; BAE27392.1; CAA33777.1; CAA33777.1; CAA33777.1; CAA33777.1; CAA33777.1; CAA33777.1; CAA33777.1 

Protein Name

 U1 small nuclear ribonucleoprotein 70 kDa 

Protein Synonyms/Alias

 U1 snRNP 70 kDa; U1-70K; snRNP70 

Gene Name

 Snrnp70 

Gene Synonyms/Alias

 Snrp70 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	PYLPPLEKLPHEKHH	acetylation	[1]
27	PYLPPLEKLPHEKHH	ubiquitination	[2]
32	LEKLPHEKHHNQPYC	acetylation	[3]
118	NYDTTESKLRREFEV	acetylation	[4]
118	NYDTTESKLRREFEV	ubiquitination	[2]
162	RDMHSAYKHADGKKI	acetylation	[4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoform cannot bind U1-snRNA (By similarity). 

Sequence Annotation

 DOMAIN 103 181 RRM.
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 118 118 N6-acetyllysine (By similarity).
 MOD_RES 226 226 Phosphoserine.
 MOD_RES 268 268 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine (By similarity).
 MOD_RES 408 408 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 448 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR022023; U1snRNP70_N. 

Pfam

 PF00076; RRM_1
 PF12220; U1snRNP70_N 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS