UniProt Accession

 CNN3_MOUSE; Q9DAW9; Q3TW23 

Genbank Protein ID

 AK005460; AK051628; AK159555; AK159871; AK166578; AK167201; AK167613; AK169021; AK169098; AK169410; BC055711; BC085268 

Genbank Nucleotide ID

 BAB24051.1; BAC34697.1; BAE35180.1; BAE35444.1; BAE38867.1; BAE39329.1; BAE39666.1; BAE40817.1; BAE40881.1; BAE41156.1; AAH55711.1; AAH85268.1 

Protein Name

 Calponin-3 

Protein Synonyms/Alias

 Calponin, acidic isoform 

Gene Name

 Cnn3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MTHFNKGPSYGLS	acetylation	[1, 2, 3]
6	**MTHFNKGPSYGLS	ubiquitination	[4]
17	YGLSAEVKNKIASKY	ubiquitination	[4]
23	VKNKIASKYDQQAEE	acetylation	[1, 3]
156	TRRFDEGKLKAGQSV	acetylation	[2]
158	RFDEGKLKAGQSVIG	ubiquitination	[4]
251	SLQMGTNKVASQKGM	ubiquitination	[4]
256	TNKVASQKGMSVYGL	acetylation	[1, 3]
256	TNKVASQKGMSVYGL	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). 

Sequence Annotation

 DOMAIN 26 129 CH.
 REPEAT 164 189 Calponin-like 1.
 REPEAT 204 229 Calponin-like 2.
 REPEAT 243 268 Calponin-like 3.  

Keyword

 Actin-binding; Calmodulin-binding; Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0031032; P:actomyosin structure organization; IEA:InterPro. 

Interpro

 IPR001997; Calponin.
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin. 

Pfam

 PF00402; Calponin
 PF00307; CH 

SMART

 SM00033; CH 

PROSITE

 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 

PRINTS

 PR00889; CALPONIN.
 PR00888; SM22CALPONIN.