| Tag | Content |
|---|
| CPLM ID | CPLM-007196 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 52 |
Protein Synonyms/Alias | Suppressor of actin mutation protein 2 |
Gene Name | VPS52 |
Gene Synonyms/Alias | SAC2; YDR484W; D8035.27 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | NNLDQDNKDAENSAM | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. May also be involved in the actin cytoskeleton organization. |
Sequence Annotation | MOD_RES 602 602 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 641 AA |
Protein Sequence | MDVLKEVLSL DQDKFDQLKE TSRDKTNETD DPFENYLKDC KFKAPSNKDQ SPFAKLKSLQ 60
ETHSNNEAAI NIIIPQLIDY LTEFTNRLSN YTQDLDFIKK KSNELQSLLE YNSTKLAHIS 120
PMVNDLMIPP ELIDDIIKGK INESWQDNIT FIADKEEIYN KYRSNNLDQD NKDAENSAML 180
APKDFDKLCQ LLDILKNVIL ERSKRLIISK IKTLRSHNPV PSQRIQNKLL KVQKIFPFIR 240
DNNLSLALEL RQAYCYTMKW YYREYFSRYI RSLTILQFQQ IDSQFALGNG LSTTSVSGFN 300
NSPSLFFSNY LTTSASNAFY NKLPVTDEKI DKYFQIKKRL NILTQEDNTV MVSQIAENNT 360
TKNYIEIGFK NLNLAILDNC TVEYHFLKDF FAMNGDNFEE INGLLEQIFQ PTFDEATTYT 420
QQLIQYNYDI FGVLISIRVA NQLQFESERR GIPSMFDSFL NGQLIQLWPR FQQLVDFQCE 480
SLRKAAITTN VAKYAGNSST SNSSPLTSPH ELTVQFGKFL SSFLTLAITH KQSIDERSEP 540
LYNSIIRLRN DFETVMTKCS KKTKSPERFL ATNYMYLYNN LQQLHLHLNI NDSDAQNYNF 600
DSAENVGTKV ANDDDNDSSV PLIIRETENH FKTLVEAFTR N 641 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0000938; C:GARP complex; IPI:SGD. GO:0030029; P:actin filament-based process; IGI:SGD. GO:0006896; P:Golgi to vacuole transport; IMP:SGD. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0042147; P:retrograde transport, endosome to Golgi; IDA:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |