CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023468
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable citrate synthase, mitochondrial 
Protein Synonyms/Alias
 Protein knockdown 
Gene Name
 kdn 
Gene Synonyms/Alias
 l(1)G0030; CG3861 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
184NHDSKFAKAYSDGVHacetylation[1]
330NPSEEQLKEYIWKTLacetylation[1]
335QLKEYIWKTLKSGQVacetylation[1]
338EYIWKTLKSGQVVPGacetylation[1]
383QLVSKIYKVVPPILTacetylation[1]
394PILTETGKVKNPWPNacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Plays a role in controlling neuronal activity and seizure susceptibility. 
Sequence Annotation
 ACT_SITE 302 302 By similarity.
 ACT_SITE 348 348 By similarity.
 ACT_SITE 403 403 By similarity.  
Keyword
 Alternative splicing; Behavior; Complete proteome; Mitochondrion; Reference proteome; Transferase; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MSLYRISARK LSEAQKLPNV GAYVRMIAAD GKSLRDVLAA KVPQEQERVK NFRKQHGATK 60
MGETTIDMMY GGMRGIKALV TETSVLDADE GIRFRGLSIP ECQKVLPAAD GGTEPLPEGL 120
FWLLLTGEVP TKSQVQQLSR EWAERAALPQ HVVTMLNNMP TTLHPMSQFA AAVTALNHDS 180
KFAKAYSDGV HKSKYWEYVY EDSMDLIAKL PVVAATIYCN TYRGGKGSRS IDSSLDWSAN 240
FVKMLGYDNA PFTELMRLYL TIHSDHEGGN VSAHTVHLVG SALSDPYLSF AAGLNGLAGP 300
LHGLANQEVL VWLRKLQKEA GNNPSEEQLK EYIWKTLKSG QVVPGYGHAV LRKTDPRYTC 360
QREFALKHLP EDETFQLVSK IYKVVPPILT ETGKVKNPWP NVDAHSGVLL QYYGMKEMNY 420
YTVLFGVSRA LGVLASLVWD RALGLPIERP KSFSTDLLVK MVQK 464 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
 GO:0004108; F:citrate (Si)-synthase activity; ISS:UniProtKB.
 GO:0007610; P:behavior; IEA:UniProtKB-KW.
 GO:0005975; P:carbohydrate metabolic process; ISS:UniProtKB.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016142; Citrate_synth-like_lrg_a-sub.
 IPR002020; Citrate_synthase-like.
 IPR016141; Citrate_synthase-like_core.
 IPR019810; Citrate_synthase_AS.
 IPR010109; Citrate_synthase_euk. 
Pfam
 PF00285; Citrate_synt 
SMART
  
PROSITE
 PS00480; CITRATE_SYNTHASE 
PRINTS
 PR00143; CITRTSNTHASE.