CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007653
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerol-3-phosphate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 GPD-M; GPDH-M; mtGPD 
Gene Name
 GPD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
504LAATYGDKAFEVAKMubiquitination[1]
634RYKKRFHKFDADQKGacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 DOMAIN 623 658 EF-hand 1.
 DOMAIN 659 694 EF-hand 2.
 NP_BIND 71 99 FAD (Potential).
 MOD_RES 600 600 Phosphotyrosine (By similarity).
 MOD_RES 601 601 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Metal-binding; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 727 AA 
Protein Sequence
MAFQKAVKGT ILVGGGALAT VLGLSQFAHY RRKQMNLAYV KAADCISEPV NREPPSREAQ 60
LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR 120
YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI MLPVYKWWQL PYYWVGIKLY 180
DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG 240
AATANYMEVV SLLKKTDPQT GKVRVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM 300
DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD 360
VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTQSISRNH 420
VVDISESGLI TIAGGKWTTY RSMAEDTINA AVKTHNLKAG PSRTVGLFLQ GGKDWSPTLY 480
IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG 540
IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDYKKQE QLETARKFLY 600
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR VLESINVQMD 660
ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV 720
DRSCGGL 727 
Gene Ontology
 GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0004368; F:glycerol-3-phosphate dehydrogenase activity; TAS:ProtInc.
 GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:EC.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0006094; P:gluconeogenesis; IEA:Compara.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR006076; FAD-dep_OxRdtase.
 IPR000447; G3P_DH_FAD-dep. 
Pfam
 PF01266; DAO
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00977; FAD_G3PDH_1
 PS00978; FAD_G3PDH_2 
PRINTS
 PR01001; FADG3PDH.