CPLM-001777

Genbank Nucleotide ID

Hypoxanthine-guanine phosphoribosyltransferase

Protein Synonyms/Alias

HGPRT; HGPRTase; HPRT B

Mus musculus (Mouse)

Position	Peptide	Type	References
103	TVDFIRLKSYCNDQS	acetylation	[1, 2]
103	TVDFIRLKSYCNDQS	ubiquitination	[3]
115	DQSTGDIKVIGGDDL	acetylation	[4]
115	DQSTGDIKVIGGDDL	ubiquitination	[3]
151	QTLLSLVKQYSPKMV	acetylation	[1]
151	QTLLSLVKQYSPKMV	ubiquitination	[3]
159	QYSPKMVKVASLLVK	ubiquitination	[3]
166	KVASLLVKRTSRSVG	acetylation	[1]

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]

Functional Description

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).

NP_BIND 134 142 GMP (By similarity).
NP_BIND 186 188 GMP (By similarity).
ACT_SITE 138 138 Proton acceptor (By similarity).
METAL 194 194 Magnesium (By similarity).
BINDING 69 69 GMP (By similarity).
BINDING 166 166 GMP (By similarity).
BINDING 194 194 GMP; via carbonyl oxygen (By similarity).

Complete proteome; Cytoplasm; Direct protein sequencing; Glycosyltransferase; Magnesium; Metal-binding; Nucleotide-binding; Purine salvage; Reference proteome; Transferase.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; IBA:RefGenome.
GO:0052657; F:guanine phosphoribosyltransferase activity; ISS:UniProtKB.
GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IDA:MGI.
GO:0000287; F:magnesium ion binding; IBA:RefGenome.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO:0006168; P:adenine salvage; IMP:MGI.
GO:0021954; P:central nervous system neuron development; IMP:MGI.
GO:0021895; P:cerebral cortex neuron differentiation; IMP:MGI.
GO:0019835; P:cytolysis; IMP:MGI.
GO:0048813; P:dendrite morphogenesis; IMP:MGI.
GO:0042417; P:dopamine metabolic process; IMP:MGI.
GO:0046038; P:GMP catabolic process; ISS:UniProtKB.
GO:0032263; P:GMP salvage; IBA:RefGenome.
GO:0007625; P:grooming behavior; IGI:MGI.
GO:0006178; P:guanine salvage; IMP:MGI.
GO:0043103; P:hypoxanthine salvage; ISS:UniProtKB.
GO:0032264; P:IMP salvage; IBA:RefGenome.
GO:0007626; P:locomotory behavior; IMP:MGI.
GO:0046651; P:lymphocyte proliferation; IMP:MGI.
GO:0045964; P:positive regulation of dopamine metabolic process; IMP:MGI.
GO:0051289; P:protein homotetramerization; IEA:Compara.
GO:0006166; P:purine ribonucleoside salvage; IMP:MGI.
GO:0001975; P:response to amphetamine; IMP:MGI.
GO:0021756; P:striatum development; IMP:MGI.

IPR005904; Hxn_phspho_trans.
IPR000836; PRibTrfase_dom.

PF00156; Pribosyltran

PS00103; PUR_PYR_PR_TRANSFER