CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039688
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Importin subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 KPNA6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14ETMASPGKDNYRMKSubiquitination[1]
23NYRMKSYKNNALNPEubiquitination[1, 2, 3, 4]
54KREQQLFKRRNVELIubiquitination[2, 4]
115KFRKLLSKEPSPPIDubiquitination[1, 3, 4, 5]
139DRFVEFLKRNENCTLubiquitination[3, 4]
254NPPPEFAKVSPCLPVubiquitination[1]
359SPKESIRKEACWTISubiquitination[1, 2, 6]
401KAEFRTRKEAAWAITubiquitination[1, 3, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Functions in nuclear protein import (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MKSYVSETMA SPGKDNYRMK SYKNNALNPE EMRRRREEEG IQLRKQKREQ QLFKRRNVEL 60
INEEAAMFDS LLMDSYVSST TGESVITREM VEMLFSDDSD LQLATTQKFR KLLSKEPSPP 120
IDEVINTPRV VDRFVEFLKR NENCTLQFEA AWALTNIASG TSQQTKIVIE AGAVPIFIEL 180
LNSDFEDVQE QAVWALGNIA GDSSVCRDYV LNCSILNPLL TLLTKSTRLT MTRNAVWALS 240
NLCRGKNPPP EFAKVSPCLP VLSRLLFSSD SDLLADACWA LSYLSDGPNE KIQAVIDSGV 300
CRRLVELLMH NDYKVASPAL RAVGNIVTGD DIQTQVILNC SALPCLLHLL SSPKESIRKE 360
ACWTISNITA GNRAQIQAVI DANIFPVLIE ILQKAEFRTR KEAAWAITNA TSGGTPEQIR 420
YLVSLGCIKP LCDLLTVMDS KIVQVALNGL ENILRLGEQE GKRSGSGVNP YCGLIEEAYG 480
LDKIEFLQSH ENQEIYQKAF DLIEHYFGVE DDDSSLAPQV DETQQQFIFQ QPEAPMEGFQ 540
L 541 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006606; P:protein import into nucleus; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo.
 IPR002652; Importin-a_IBB.
 IPR024931; Importing_su_alpha. 
Pfam
 PF00514; Arm
 PF01749; IBB 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT
 PS51214; IBB 
PRINTS