CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Mthfd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10PAGILNGKLVSAQIRubiquitination[1]
134LTSVSAGKLARGDLNubiquitination[1]
157KGCLELIKEAGVQIAubiquitination[1]
208NLDKEVNKGDILVVAubiquitination[1]
251DTKPNGRKVVGDVAYubiquitination[1]
262DVAYDEAKERASFITubiquitination[1]
309KWTIQYNKLNLKTPVubiquitination[1]
313QYNKLNLKTPVPSDIubiquitination[1]
329ISRSCKPKLIGNLARubiquitination[1]
352VELYGETKAKVLLSAubiquitination[1]
354LYGETKAKVLLSALDubiquitination[1]
370LKHQPDGKYVVVTGIubiquitination[1]
473HELTQTDKALFNRLVubiquitination[1]
488PSVNGIRKFSDIQIRubiquitination[1]
504LRRLGIEKTDPTTLTubiquitination[1]
543TNDRFLRKITIGQSPubiquitination[1]
553IGQSPTEKGHTRTAQubiquitination[1]
620VLMKDAIKPNLMQTLubiquitination[1]
684MEKFFNIKCRYSGLQubiquitination[1]
721TAGLPLPKAYTEEDLubiquitination[1]
733EDLDLVEKGFSNLRKubiquitination[1]
784HGAFDAVKCTHWAEGubiquitination[1]
848LLPEAQNKAEIYTKQubiquitination[1]
854NKAEIYTKQGFGNLPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 935 AA 
Protein Sequence
MAPAGILNGK LVSAQIRDRL KNQVTRMQVQ VPGFTPGLAI LQVGDRDDSN LYINVKLKAA 60
EEIGIKATHI KLPRTSTESE VLKYVISLNE DASVHGFIVQ LPLDSENSIN TEAVINAIAP 120
EKDVDGLTSV SAGKLARGDL NDCFIPCTPK GCLELIKEAG VQIAGRHAVV VGRSKIVGAP 180
MHDLLLWNNA TVTTCHSKTA NLDKEVNKGD ILVVATGQPE MVKGEWIKPG AVVIDCGINY 240
VPDDTKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AQRFLQKFKP 300
GKWTIQYNKL NLKTPVPSDI AISRSCKPKL IGNLAREIGL LTEEVELYGE TKAKVLLSAL 360
DRLKHQPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LRQNVFACVR QPSQGPTFGI 420
KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV 480
PSVNGIRKFS DIQIRRLRRL GIEKTDPTTL TDDEINRFAR LDIDPETITW QRVLDTNDRF 540
LRKITIGQSP TEKGHTRTAQ FDISVASEIM AVLALTSSLE DMRERLGRMV VASSKKGEPI 600
SCEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG 660
PEGFVVTEAG FGADIGMEKF FNIKCRYSGL QPHVVVLVAT VRALKMHGGG PTVTAGLPLP 720
KAYTEEDLDL VEKGFSNLRK QIENARMFGV PVVVAVNVFK TDTDAELDLV SRLSREHGAF 780
DAVKCTHWAE GGQGALALAQ AVQRASQAPS SFQLLYDLKL SIEDKIRIIA QRIYGADDIE 840
LLPEAQNKAE IYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFVLPIRD IRASVGAGFL 900
YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF 935 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004329; F:formate-tetrahydrofolate ligase activity; IBA:RefGenome.
 GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IBA:RefGenome.
 GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IBA:RefGenome.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IBA:RefGenome. 
Interpro
 IPR000559; Formate_THF_ligase.
 IPR020628; Formate_THF_ligase_CS.
 IPR016040; NAD(P)-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR000672; THF_DH/CycHdrlase.
 IPR020630; THF_DH/CycHdrlase_cat_dom.
 IPR020867; THF_DH/CycHdrlase_CS.
 IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. 
Pfam
 PF01268; FTHFS
 PF00763; THF_DHG_CYH
 PF02882; THF_DHG_CYH_C 
SMART
  
PROSITE
 PS00721; FTHFS_1
 PS00722; FTHFS_2
 PS00766; THF_DHG_CYH_1
 PS00767; THF_DHG_CYH_2 
PRINTS
 PR00085; THFDHDRGNASE.