UniProt Accession

 3HAO_MOUSE; Q78JT3; Q52L88 

Genbank Protein ID

 BC012872; BC094021 

Genbank Nucleotide ID

 AAH12872.1; AAH94021.1 

Protein Name

 3-hydroxyanthranilate 3,4-dioxygenase 

Protein Synonyms/Alias

 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD 

Gene Name

 Haao 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MERRVRVKSWVEENR	ubiquitination	[1]
25	FQPPVCNKLMHQEQL	ubiquitination	[1]
33	LMHQEQLKIMFVGGP	ubiquitination	[1]
130	TEDVLFEKWFHCKDL	ubiquitination	[1]
158	SEQYRTGKPNPDQLL	ubiquitination	[1]
166	PNPDQLLKELPFPLN	ubiquitination	[1]
179	LNTRSIMKPMSLKAW	ubiquitination	[1]
184	IMKPMSLKAWLDGHS	ubiquitination	[1]
220	AHGQGSSKGPRQDVD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity). 

Sequence Annotation

 REGION 1 160 Domain A (catalytic) (By similarity).
 REGION 161 177 Linker (By similarity).
 REGION 178 286 Domain B (By similarity).
 METAL 47 47 Iron; catalytic (By similarity).
 METAL 53 53 Iron; catalytic (By similarity).
 METAL 91 91 Iron; catalytic (By similarity).
 BINDING 43 43 Dioxygen (By similarity).
 BINDING 53 53 Substrate (By similarity).
 BINDING 95 95 Substrate (By similarity).
 BINDING 105 105 Substrate (By similarity).
 MOD_RES 9 9 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Pyridine nucleotide biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IDA:MGI.
 GO:0008198; F:ferrous iron binding; IEA:HAMAP.
 GO:0019825; F:oxygen binding; IEA:Compara.
 GO:0043420; P:anthranilate metabolic process; IEA:HAMAP.
 GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP.
 GO:0070050; P:neuron homeostasis; IEA:Compara.
 GO:0019805; P:quinolinate biosynthetic process; IEA:HAMAP.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0006569; P:tryptophan catabolic process; IEA:HAMAP. 

Interpro

 IPR010329; 3hydroanth_dOase.
 IPR016700; 3hydroanth_dOase_met.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF06052; 3-HAO 

SMART

  

PROSITE

  

PRINTS