CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024558
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor kayak, isoforms D/sro 
Protein Synonyms/Alias
 AP-1; Fos-related antigen; Dfos; dFra 
Gene Name
 kay 
Gene Synonyms/Alias
 Fra; CG15509 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
718TPTAEPSKLVSL***acetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra. 
Sequence Annotation
 DOMAIN 385 448 bZIP.
 REGION 387 406 Basic motif (By similarity).
 REGION 413 420 Leucine-zipper (By similarity).
 MOD_RES 515 515 Phosphoserine.  
Keyword
 Activator; Alternative promoter usage; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 722 AA 
Protein Sequence
MIALKATEMQ HNNNALQQQQ QLQHQLLQQH QQQHQQQLQQ QLNSPDNNYI WATTHNANIS 60
RNNAMLQLQQ QQLRAPWITD CNKQHHINNN NSMNVNYNQQ LTQQPQQQQQ QTQYMQHNYN 120
NYTQQQQQQH LVPATTSQSN SHFYQCNQQQ QQQQFLAPTT TTAAVVVAAA HQQHQTQQQH 180
QSQQQQQHQR QDYASLQMGR QLGNFETGQS VLTLTTPTLT PTTTRNIEDT LGHLLSDTQT 240
DRVAGCAGFA VPKVLPNAID VLGMGIPTGV SSLPLQQTFD LSLGQGSESE DSNASYNDTQ 300
MNEEQDTTDT SSAHTDSTSY QAGHIMAGSV NGGGVNNFSN VLAAVSSSRG SASVGSSNAN 360
TSNTPARRGG GRRPNRSTNM TPEEEQKRAV RRERNKQAAA RCRKRRVDQT NELTEEVEQL 420
EKRGESMRKE IEVLTNSKNQ LEYLLATHRA TCQKIRSDML SVVTCNGLIA PAGLLSAGSS 480
GSGASSHHNH NSNDSSNGTI TGMDATLNST GRSNSPLDLK PAANIDSLLM HIKDEPLDGA 540
IDSGSSLDQD GPPPSKRITL PPMSTMPHVH LSTILTPTGA SSGSLQTPIT STAPGGFGSA 600
FPVTSNGSSI NNINSIGNNM NSPTLNAHNK VPKERPNTLA FQRPLGQMHL TMANNKAGGP 660
TQIQGVPIQT PSTGTFNFDS LMDGGTGLTP VSGPLVPNSS STNKHPLELP TPTAEPSKLV 720
SL 722 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005667; C:transcription factor complex; IPI:FlyBase.
 GO:0046982; F:protein heterodimerization activity; ISS:FlyBase.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
 GO:0008134; F:transcription factor binding; TAS:FlyBase.
 GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
 GO:0007298; P:border follicle cell migration; IGI:FlyBase.
 GO:0048674; P:collateral sprouting of injured axon; IMP:FlyBase.
 GO:0007391; P:dorsal closure; IMP:FlyBase.
 GO:0007281; P:germ cell development; IMP:FlyBase.
 GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.
 GO:0007254; P:JNK cascade; NAS:FlyBase.
 GO:0045475; P:locomotor rhythm; IMP:FlyBase.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0031660; P:regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle; IMP:FlyBase.
 GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IMP:FlyBase.
 GO:0051124; P:synaptic growth at neuromuscular junction; IGI:FlyBase.
 GO:0035220; P:wing disc development; IMP:FlyBase.
 GO:0042060; P:wound healing; IMP:FlyBase. 
Interpro
 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS
 PR00042; LEUZIPPRFOS.