CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011148
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial DNA replication protein YHM2 
Protein Synonyms/Alias
  
Gene Name
 YHM2 
Gene Synonyms/Alias
 YMR241W; YM9408.03 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
160QSSWSVFKNIYKKEGacetylation[1]
173EGIRGINKGVNAVAIacetylation[1]
259PKNLTVGKTFKYIYQacetylation[1]
262LTVGKTFKYIYQSNGacetylation[1]
271IYQSNGLKGLYRGVTacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 May function as a member of the protein machinery for the mitochondrial inner membrane attachment site of mitochondrial DNA during replication and segregation of mitochondrial genomes. Binds to DNA in vitro. 
Sequence Annotation
 REPEAT 18 100 Solcar 1.
 REPEAT 107 199 Solcar 2.
 REPEAT 217 301 Solcar 3.
 DNA_BIND 245 254  
Keyword
 Complete proteome; DNA-binding; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MPSTTNTAAA NVIEKKPVSF SNILLGACLN LSEVTTLGQP LEVVKTTMAA NRNFTFLESV 60
KHVWSRGGIL GYYQGLIPWA WIEASTKGAV LLFVSAEAEY RFKSLGLNNF ASGILGGVTG 120
GVTQAYLTMG FCTCMKTVEI TRHKSASAGG VPQSSWSVFK NIYKKEGIRG INKGVNAVAI 180
RQMTNWGSRF GLSRLVEDGI RKITGKTNKD DKLNPFEKIG ASALGGGLSA WNQPIEVIRV 240
EMQSKKEDPN RPKNLTVGKT FKYIYQSNGL KGLYRGVTPR IGLGIWQTVF MVGFGDMAKE 300
FVARMTGETP VAKH 314 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005743; C:mitochondrial inner membrane; ISS:SGD.
 GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
 GO:0003677; F:DNA binding; IDA:SGD.
 GO:0005371; F:tricarboxylate secondary active transmembrane transporter activity; IDA:SGD.
 GO:0015742; P:alpha-ketoglutarate transport; IDA:SGD.
 GO:0006843; P:mitochondrial citrate transport; IDA:SGD.
 GO:0000002; P:mitochondrial genome maintenance; IMP:SGD. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS