UniProt Accession

 Q8K3R4_RAT; Q8K3R4 

Genbank Protein ID

 AABR06069326; AABR06069327; AABR06069328; BC092565; AY033885; CH473999 

Genbank Nucleotide ID

 AAH92565.1; AAK61608.1; EDL78080.1 

Protein Name

 30 kDa adipocyte complement-related protein 

Protein Synonyms/Alias

 Adiponectin, C1Q and collagen domain containing; Protein Adipoq 

Gene Name

 Adipoq 

Gene Synonyms/Alias

 Acdc; rCG_36676 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
177	DVKVSLFKKDKAVLF	acetylation	[1]
180	VSLFKKDKAVLFTYD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

  

Keyword

 Collagen; Complete proteome; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0071944; C:cell periphery; ISS:UniProtKB.
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0005179; F:hormone activity; IDA:RGD.
 GO:0033691; F:sialic acid binding; IEA:Compara.
 GO:0033211; P:adiponectin-mediated signaling pathway; IDA:RGD.
 GO:0050873; P:brown fat cell differentiation; ISS:UniProtKB.
 GO:0071320; P:cellular response to cAMP; IDA:RGD.
 GO:0035690; P:cellular response to drug; ISS:UniProtKB.
 GO:0071872; P:cellular response to epinephrine stimulus; IDA:RGD.
 GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.
 GO:0007623; P:circadian rhythm; IEP:RGD.
 GO:0070994; P:detection of oxidative stress; ISS:UniProtKB.
 GO:0006635; P:fatty acid beta-oxidation; ISS:UniProtKB.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
 GO:0034383; P:low-density lipoprotein particle clearance; ISS:UniProtKB.
 GO:0051899; P:membrane depolarization; IDA:RGD.
 GO:0060081; P:membrane hyperpolarization; IDA:RGD.
 GO:0045776; P:negative regulation of blood pressure; ISS:UniProtKB.
 GO:2000279; P:negative regulation of DNA biosynthetic process; ISS:UniProtKB.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0045599; P:negative regulation of fat cell differentiation; ISS:UniProtKB.
 GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.
 GO:0030853; P:negative regulation of granulocyte differentiation; ISS:UniProtKB.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISS:UniProtKB.
 GO:0046888; P:negative regulation of hormone secretion; IDA:RGD.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
 GO:0090317; P:negative regulation of intracellular protein transport; ISS:UniProtKB.
 GO:0045715; P:negative regulation of low-density lipoprotein particle receptor biosynthetic process; ISS:UniProtKB.
 GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; ISS:UniProtKB.
 GO:0045650; P:negative regulation of macrophage differentiation; ISS:UniProtKB.
 GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
 GO:2000590; P:negative regulation of metanephric mesenchymal cell migration; ISS:UniProtKB.
 GO:0050765; P:negative regulation of phagocytosis; ISS:UniProtKB.
 GO:2000584; P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; ISS:UniProtKB.
 GO:0031953; P:negative regulation of protein autophosphorylation; ISS:UniProtKB.
 GO:0014912; P:negative regulation of smooth muscle cell migration; ISS:UniProtKB.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISS:UniProtKB.
 GO:0050805; P:negative regulation of synaptic transmission; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
 GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; ISS:UniProtKB.
 GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
 GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; ISS:UniProtKB.
 GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.
 GO:0045923; P:positive regulation of fatty acid metabolic process; ISS:UniProtKB.
 GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
 GO:2000467; P:positive regulation of glycogen (starch) synthase activity; IDA:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
 GO:2000478; P:positive regulation of metanephric glomerular visceral epithelial cell development; ISS:UniProtKB.
 GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; ISS:UniProtKB.
 GO:0033034; P:positive regulation of myeloid cell apoptotic process; ISS:UniProtKB.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:RGD.
 GO:0010739; P:positive regulation of protein kinase A signaling cascade; ISS:UniProtKB.
 GO:2000534; P:positive regulation of renal albumin absorption; ISS:UniProtKB.
 GO:0070208; P:protein heterotrimerization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0070543; P:response to linoleic acid; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0009744; P:response to sucrose stimulus; IEP:RGD.
 GO:0034612; P:response to tumor necrosis factor; ISS:UniProtKB. 

Interpro

 IPR001073; C1q.
 IPR008160; Collagen.
 IPR008983; Tumour_necrosis_fac-like_dom. 

Pfam

 PF00386; C1q
 PF01391; Collagen 

SMART

 SM00110; C1Q 

PROSITE

 PS50871; C1Q 

PRINTS

 PR00007; COMPLEMNTC1Q.