CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031704
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Septin-2 
Protein Synonyms/Alias
  
Gene Name
 SEPT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34VIPGAAEKIERTVQIubiquitination[1, 2]
143NIVPVIAKADTLTLKubiquitination[1, 3, 4]
150KADTLTLKERERLKKubiquitination[1, 3]
192KEQTRLLKASIPFSVubiquitination[1, 3, 4, 5]
209SNQLIEAKGKKVRGRubiquitination[1, 2, 5]
211QLIEAKGKKVRGRLYubiquitination[1]
212LIEAKGKKVRGRLYPubiquitination[1]
235PEHNDFLKLRTMLITubiquitination[1, 2, 5]
270RLKRGGRKVENEDMNubiquitination[1, 3, 4]
278VENEDMNKDQILLEKubiquitination[1, 2, 3, 4]
285KDQILLEKEAELRRMubiquitination[3, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 321 AA 
Protein Sequence
MVVGESGLGK STLINSLFLT DLYPERVIPG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV 60
DTPGYGDAIN CRDCFKTIIS YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL 120
KPLDVAFMKA IHNKVNIVPV IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE 180
DEDFKEQTRL LKASIPFSVV GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML 240
ITHMQDLQEV TQDLHYENFR SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ 300
AQMQMQMQGG DGDGGALGHH V 321 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0060170; C:cilium membrane; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000145; C:exocyst; IEA:Compara.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0030234; F:enzyme regulator activity; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0002036; P:regulation of L-glutamate transport; IEA:Compara.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin.
 IPR008113; Septin2. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS
 PR01740; SEPTIN2.