UniProt Accession

 CEBPA_RAT; P05554 

Genbank Protein ID

 X12752 

Genbank Nucleotide ID

 CAA31242.1 

Protein Name

 CCAAT/enhancer-binding protein alpha 

Protein Synonyms/Alias

 C/EBP alpha 

Gene Name

 Cebpa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
159	ALRPLVIKQEPREED	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. 

Sequence Annotation

 DOMAIN 282 345 bZIP.
 REGION 286 313 Basic motif (By similarity).
 REGION 317 345 Leucine-zipper (By similarity).
 MOD_RES 159 159 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Activator; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0016363; C:nuclear matrix; IDA:RGD.
 GO:0035189; C:Rb-E2F complex; IDA:RGD.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0006953; P:acute-phase response; IEP:RGD.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0030154; P:cell differentiation; IEP:RGD.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0030225; P:macrophage differentiation; IEA:Compara.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0045600; P:positive regulation of fat cell differentiation; IMP:RGD.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0033274; P:response to vitamin B2; IEP:RGD.
 GO:0000050; P:urea cycle; IEA:Compara.
 GO:0050872; P:white fat cell differentiation; IEA:Compara. 

Interpro

 IPR004827; bZIP.
 IPR016468; CCAAT/enhancer-binding. 

Pfam

 PF07716; bZIP_2 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS