CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat-containing protein 36 
Protein Synonyms/Alias
  
Gene Name
 WDR36 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
179SLQLWNVKSNKLLYTubiquitination[1, 2, 3, 4]
182LWNVKSNKLLYTFPGubiquitination[2]
228KFNETLMKFRQDWGPubiquitination[1, 2, 5]
266GLWDLEDKKLINQMRubiquitination[2, 3]
267LWDLEDKKLINQMRNubiquitination[2, 3]
357SFSTVHEKFNKSLGHubiquitination[1, 2, 3, 5, 6, 7]
360TVHEKFNKSLGHGLIubiquitination[2, 4]
369LGHGLINKKRVKRKGacetylation[8]
370GHGLINKKRVKRKGLubiquitination[2]
375NKKRVKRKGLQNTMSubiquitination[2]
390VRLPPITKFAAEEARubiquitination[1, 2, 3, 4, 5, 6, 7]
430TIGAYFLKPKELKKDubiquitination[2, 4]
478IHRGSFGKDQAHKGSubiquitination[2, 4]
483FGKDQAHKGSVRGVAubiquitination[2, 4]
515KFWNFKNKILIHSVSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 581 AA 
Protein Sequence
MERASERRTA SALFAGFRAL GLFSNDIPHV VRFSALKRRF YVTTCVGKSF HTYDVQKLSL 60
VAVSNSVPQD ICCMAADGRL VFAAYGNVFS AFARNKEIVH TFKGHKAEIH FLQPFGDHII 120
SVDTDGILII WHIYSEEEYL QLTFDKSVFK ISAILHPSTY LNKILLGSEQ GSLQLWNVKS 180
NKLLYTFPGW KVGVTALQQA PAVDVVAIGL MSGQVIIHNI KFNETLMKFR QDWGPITSIS 240
FRTDGHPVMA AGSPCGHIGL WDLEDKKLIN QMRNAHSTAI AGLTFLHREP LLVTNGADNA 300
LRIWIFDGPT GEGRLLRFRM GHSAPLTNIR YYGQNGQQIL SASQDGTLQS FSTVHEKFNK 360
SLGHGLINKK RVKRKGLQNT MSVRLPPITK FAAEEARESD WDGIIACHQG KLSCSTWNYQ 420
KSTIGAYFLK PKELKKDDIT ATAVDITSCG NFAVIGLSSG TVDVYNMQSG IHRGSFGKDQ 480
AHKGSVRGVA VDGLNQLTVT TGSEGLLKFW NFKNKILIHS VSLSSSPNIM LLHRDSGILG 540
LALDDFSISV LDIETRKIVR EFSGHQGQIN DMVKQTLTNK T 581 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS