| Tag | Content |
|---|
| CPLM ID | CPLM-004703 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
Protein Synonyms/Alias | Phosphorylase kinase alpha M subunit |
Gene Name | Phka1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | GIWERGDKTNQGISE | ubiquitination | [1] | | 361 | ALDAVLIKGKNGVPL | ubiquitination | [1] | | 706 | DLMSLVAKAKELHIQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
Sequence Annotation | REGION 811 841 Calmodulin-binding (Potential).
REGION 1064 1104 Calmodulin-binding (Potential).
MOD_RES 200 200 Phosphoserine.
MOD_RES 201 201 Phosphoserine.
MOD_RES 736 736 Phosphoserine (By similarity).
MOD_RES 759 759 Phosphoserine (By similarity).
MOD_RES 973 973 Phosphoserine; by autocatalysis (By
MOD_RES 986 986 Phosphoserine; by autocatalysis (By
MOD_RES 1008 1008 Phosphoserine; by autocatalysis (By
MOD_RES 1019 1019 Phosphoserine; by PKA (By similarity).
MOD_RES 1021 1021 Phosphoserine (By similarity).
MOD_RES 1024 1024 Phosphoserine (By similarity).
LIPID 1238 1238 S-farnesyl cysteine (By similarity). |
Keyword | Alternative splicing; Calmodulin-binding; Carbohydrate metabolism; Cell membrane; Complete proteome; Glycogen metabolism; Lipoprotein; Membrane; Muscle protein; Phosphoprotein; Prenylation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1241 AA |
Protein Sequence | MRSRSNSGVR LDGYARLVHQ TILCHQNPVT GLLPASYDQK DAWVRDNVYS ILAVWGLGLA 60
YRKNADRDED KAKAYELEQS VVKLMRGLLH CMIRQVDKVE SFKYSQSTKD SLHAKYNTKT 120
CATVVGDDQW GHLQLDATSV YLLFLAQMTA SGLHIIHSLD EVNFIQNLVF YIEAAYKTAD 180
FGIWERGDKT NQGISELNAS SVGMAKAALE ALDELDLFGV KGGPQSVIHV LADEVQHCQS 240
ILNSLLPRAS TSKEVDASLL SVVSFPAFAV EDSHLVELTK QEIITKLQGR YGCCRFLRDG 300
YKTPKEDPNR LYYEPAELKL FENIECEWPL FWTYFILDGI FSGNVEQVQE YREALDAVLI 360
KGKNGVPLLP ELYSVPPDRV DEEYQNPHTV DRVPMGKLPH MWGQSLYILG SLMAEGFLAP 420
GEIDPLNRRF STVPKPDVVV QVSILAETEE IKAILKDKGI DVETIAEVYP IRVQPARILS 480
HIYSSLGCNS RMKLSGRPYR LMGVLGTSKL YDIRKTIFTF TPQFIDQQQF YLALDNQMIV 540
EMLRTDLSYL CSRWRMTGQP TITFPISHTM LDEDGTSLNS SILAALRKMQ DGYFGGARIQ 600
TGKLSEFLTT SCCTHLSFMD PGPEGKLYSE DYDEDYEDDL DSGNWMDSYD STSNARCGDE 660
VARYLDRLLA HTVPHPKLAP TSRKGGLDRF RAAVQTTCDL MSLVAKAKEL HIQNVHMYLP 720
TKLFQPSRPS LNLLDSPESP QDSQVPSVHV EVHLPRDQSG EVDFQSLVSQ LKETSSLQEQ 780
ADILYMLYSM KGPDWNTELY EEGGATVREL LSELYVKVGE IRHWGLIRYI SGILRKKVEA 840
LDEACTDLLS YQKHLTVGLP PEPREKTISA PLPYEALTKL IDEASEGDMS ISTLTQEIMV 900
YLAMYMRTQP GLFAEMFRLR IGLIIQVMAT ELAHSLRCSA EEATEGLMNL SPSAMKNLLH 960
HILSGKEFGV ERSVRPTDSN VSPAISIHEI GAVGATKTER TGIMQLKSEI KQVEFRRLSV 1020
SMESQTSGGH PSGVDLMSPS FLSPAACIAA SSGSFPTVCD HQTSKDSRQG QWQRRRRLDG 1080
ALNRVPIGFY QKVWKILQKC HGLSVEGFVL PSSTTREMTP GEIKFSVHVE SVLNRVPQPE 1140
YRQLLVEAIL VLTMLADIEI HSIGSIIAVE KIVHIANDLF LQEQKTLGAD DTMLAKDPAS 1200
GICTLLYDSA PSGRFGTMTY LSKAAATYVQ EFLPHSLCAM Q 1241 |
Gene Ontology | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |