| Tag | Content |
|---|
| CPLM ID | CPLM-015849 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nexilin |
Protein Synonyms/Alias | F-actin-binding protein |
Gene Name | Nexn |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 476 | LRMQFEQKEIDAALQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in regulating cell migration through association with the actin cytoskeleton (By similarity). Has an essential role in the maintenance of Z line and sarcomere integrity (By similarity). |
Sequence Annotation | DOMAIN 513 601 Ig-like.
MOD_RES 16 16 Phosphoserine.
MOD_RES 172 172 Phosphoserine (By similarity).
MOD_RES 288 288 Phosphoserine (By similarity).
MOD_RES 296 296 Phosphoserine (By similarity).
MOD_RES 301 301 Phosphothreonine (By similarity). |
Keyword | Actin-binding; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Immunoglobulin domain; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 607 AA |
Protein Sequence | MNDVSQKAEI KEMLASDDEE ESSPKIEKAY VPKLTGTVKG KFDEMEKHRQ EEQRKRTEEE 60
RKRRIEQDLL EKRKIQRELA KRAEQIEDIN NTGTESASEE GDDSLLITVV PAKSYKTPGK 120
TKDPEDLDRE EGNGRTNHEE DKMRYEEECR VLKEAKCLSL VMDDETEAKK ESHFPGKLKS 180
TFEELERQRQ ENRKKQAEEE ARRRLEEERR SFEEARRHMV NEEDENQDRE TVFKEYRPGK 240
LKLSFEEIER QRREDEKRKA EEEARRRIEE EKAAFAEARR SMVLDDDSPE IYKTVSQESL 300
TPGKLEINFE QLLRQKMEEE RRRTEEERRH KLEMEKQEFE QLRQEMGKEE EENESFGLSR 360
EYEELIKLKR SGSIQAKNLK SKFEKIGQLS EKEVQKKIEE ERAKRRAIDL EIKEREAENF 420
HEDDDVDVRP AKKSESPFTH KVNMKARFEQ MAKAREEEEQ RRIEEQKLLR MQFEQKEIDA 480
ALQKKREDEE EEEGSIVNGS TTEDEEQTRS GAPWFKKPLR NTSVVDSEPV RFTVKVTGEP 540
KPEITWWFEG EILQDGEDYQ YIERGETYCL YLPETFPEDG GEYMCKAVNN KGSAASTCIL 600
TIEMDDY 607 |
Gene Ontology | GO:0005924; C:cell-substrate adherens junction; IEA:Compara. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0030018; C:Z disc; ISS:UniProtKB. GO:0008307; F:structural constituent of muscle; ISS:UniProtKB. GO:0030334; P:regulation of cell migration; ISS:UniProtKB. GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |