| Tag | Content |
|---|
| CPLM ID | CPLM-004017 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 2, facilitated glucose transporter member 2 |
Protein Synonyms/Alias | Glucose transporter type 2, liver; GLUT-2 |
Gene Name | Slc2a2 |
Gene Synonyms/Alias | Glut-2; Glut2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 499 | EIAAEFRKKSGSAPP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. |
Sequence Annotation | MOD_RES 519 519 Phosphoserine (By similarity).
CARBOHYD 62 62 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 522 AA |
Protein Sequence | MSEDKITGTL AFTVFTAVLG SFQFGYDIGV INAPQEVIIS HYRHVLGVPL DDRRATINYD 60
INGTDTPLIV TPAHTTPDAW EEETEGSAHI VTMLWSLSVS SFAVGGMVAS FFGGWLGDKL 120
GRIKAMLAAN SLSLTGALLM GCSKFGPAHA LIIAGRSVSG LYCGLISGLV PMYIGEIAPT 180
TLRGALGTLH QLALVTGILI SQIAGLSFIL GNQDYWHILL GLSAVPALLQ CLLLLFCPES 240
PRYLYLNLEE EVRAKKSLKR LRGTEDITKD INEMRKEKEE ASTEQKVSVI QLFTDPNYRQ 300
PIVVALMLHL AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAINMIF TAVSVLLVEK 360
AGRRTLFLAG MIGMFFCAVF MSLGLVLLDK FTWMSYVSMT AIFLFVSFFE IGPGPIPWFM 420
VAEFFSQGPR PTALALAAFS NWVCNFIIAL CFQYIADFLG PYVFFLFAGV VLVFTLFTFF 480
KVPETKGKSF DEIAAEFRKK SGSAPPRKAT VQMEFLGSSE TV 522 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IDA:RGD. GO:0031526; C:brush border membrane; IDA:RGD. GO:0005829; C:cytosol; IDA:RGD. GO:0005768; C:endosome; IDA:RGD. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB. GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB. GO:0009758; P:carbohydrate utilization; IMP:RGD. GO:0015755; P:fructose transport; IEP:RGD. GO:0009749; P:response to glucose stimulus; IEP:RGD. GO:0043434; P:response to peptide hormone stimulus; IEP:RGD. |
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