| Tag | Content |
|---|
| CPLM ID | CPLM-018847 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Caspase-10 |
Protein Synonyms/Alias | CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12 |
Gene Name | CASP10 |
Gene Synonyms/Alias | MCH4 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 271 | LNSETSTKRAAVYRM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. |
Sequence Annotation | DOMAIN 19 97 DED 1.
DOMAIN 114 187 DED 2.
ACT_SITE 358 358 By similarity.
ACT_SITE 401 401 By similarity. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Disease mutation; Hydrolase; Polymorphism; Protease; Reference proteome; Repeat; Thiol protease; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 521 AA |
Protein Sequence | MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 60
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 120
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 180
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 240
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 300
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 360
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 420
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT 480
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S 521 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc. GO:0097190; P:apoptotic signaling pathway; TAS:Reactome. GO:0006917; P:induction of apoptosis; TAS:ProtInc. GO:0045087; P:innate immune response; TAS:Reactome. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
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Pfam | |
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PROSITE | |
PRINTS | |