CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative ribosomal RNA methyltransferase NOP2 
Protein Synonyms/Alias
  
Gene Name
 NOP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
216VNLDPLGKWSKTGLVacetylation[1]
216VNLDPLGKWSKTGLVubiquitination[2, 3, 4, 5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 275 AA 
Protein Sequence
MVNHGDLWGS EDDADTVDDY GADSNSEDEE EGEALLPIER AARKQKAREA AAGIQWSEEE 60
TEDEEEEKEV TPESGPPKVE EADGGLQINV DEEPFVLPPA GEMEQDAQAP DLQRVHKRIQ 120
DIVGILRDFG AQREEGRSRS EYLNRLKKDL AIYYSYGDFL LGKLMDLFPL SELVEFLEAN 180
EVPRPVTLRT NTLKTRRRDL AQALINRGVN LDPLGKWSKT GLVVYDSSVP IGATPEYLAG 240
HYMLQGASSM LPVMALAPQE HERILDMCCA PGGKT 275 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0032259; P:methylation; IEA:GOC. 
Interpro
 IPR001678; Fmu/NOL1/Nop2p.
 IPR023273; RCMT_NOP2. 
Pfam
 PF01189; Nol1_Nop2_Fmu 
SMART
  
PROSITE
  
PRINTS
 PR02012; RCMTNOP2.