UniProt Accession

 CCS1_YEAST; P40202; D6VZL3 

Genbank Protein ID

 U17378; Z48502; AY558398; BK006946 

Genbank Nucleotide ID

 AAC49068.1; CAA88404.1; AAS56724.1; DAA09937.1 

Protein Name

 Superoxide dismutase 1 copper chaperone 

Protein Synonyms/Alias

  

Gene Name

 CCS1 

Gene Synonyms/Alias

 LYS7; YMR038C; YM9532.03C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
66	NTLRNCGKDAIIRGA	ubiquitination	[1]
141	HEKGDVSKGVESTGK	ubiquitination	[1]
167	FNESDLGKNLYSGKT	ubiquitination	[1]
226	AGVWENNKQVCACTG	ubiquitination	[1]
241	KTVWEERKDALANNI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Copper chaperone for apo superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to apo-SOD1. 

Sequence Annotation

 DOMAIN 7 70 HMA.
 METAL 16 16 Zinc; shared with apo-SOD1.
 METAL 17 17 Copper 1 (By similarity).
 METAL 20 20 Copper 1 (By similarity).
 METAL 229 229 Copper 2 (By similarity).
 METAL 231 231 Copper 2 (By similarity).
 DISULFID 27 64
 DISULFID 229 229 Interchain (with C-58 in apo-SOD1).  

Keyword

 3D-structure; Chaperone; Complete proteome; Copper; Cytoplasm; Disulfide bond; Metal-binding; Mitochondrion; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 249 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016532; F:superoxide dismutase copper chaperone activity; IMP:SGD.
 GO:0008270; F:zinc ion binding; IBA:RefGenome.
 GO:0015680; P:intracellular copper ion transport; IMP:SGD.
 GO:0055114; P:oxidation-reduction process; IEA:InterPro.
 GO:0019430; P:removal of superoxide radicals; IBA:RefGenome. 

Interpro

 IPR006121; HeavyMe-assoc_HMA.
 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR024142; SOD_Cu_chaperone.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00403; HMA
 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS01047; HMA_1
 PS50846; HMA_2 

PRINTS