CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022555
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal-induced proliferation-associated 1-like protein 2 
Protein Synonyms/Alias
 SIPA1-like protein 2 
Gene Name
 SIPA1L2 
Gene Synonyms/Alias
 KIAA1389 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
223RVENYDHKAMVPFGFubiquitination[1]
590RQASNSPKVSEQLLKubiquitination[1]
836SFITLGAKKKEKVKPubiquitination[1]
837FITLGAKKKEKVKPRubiquitination[1]
838ITLGAKKKEKVKPRKubiquitination[1]
1046RIPMVEYKLDSEGTPubiquitination[1]
1402KYVIGWKKSEGSPPPubiquitination[1]
1558GSLSDKSKCADPGLMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 595 812 Rap-GAP.
 DOMAIN 950 1026 PDZ.
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 1029 1029 Phosphoserine.
 MOD_RES 1244 1244 Phosphoserine (By similarity).
 MOD_RES 1406 1406 Phosphoserine (By similarity).
 MOD_RES 1461 1461 Phosphoserine.
 MOD_RES 1478 1478 Phosphoserine.
 MOD_RES 1488 1488 Phosphoserine.
 MOD_RES 1549 1549 Phosphoserine.
 MOD_RES 1552 1552 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1722 AA 
Protein Sequence
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS LNASNSNETG 60
GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE SRSQTSYESI TSVLQNGQSD 120
QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ RGLHPIRQRS NSDVTISDID AEDVLDQNAV 180
NPNTGAALHR EYGSTSSIDR QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI 240
SPSLHAAAQI SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 300
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN VGKRKNITTG 360
ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG KSNDLVLSCP YFRNETGGEG 420
DRRIALSRAN SSSFSSGESC SFESSLSSHC TNAGVSVLEV PRENQPIHRE KVKRYIIEHI 480
DLGAYYYRKF FYGKEHQNYF GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL 540
TTLRGAILED AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 600
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF SKYRAQLDNK 660
TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR HIGNDIVTIV FQEPGALPFT 720
PKSIRSHFQH VFVIVKVHNP CTENVCYSVG VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL 780
LAKVINAENA AHKSEKFRAM ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK 840
VKPRKDAHLF SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 900
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE MTLRRNGLGQ 960
LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA TLTHEQMIDL LRTSVTVKVV 1020
IIQPHDDGSP RRGCSELCRI PMVEYKLDSE GTPCEYKTPF RRNTTWHRVP TPALQPLSRA 1080
SPIPGTPDRL PCQQLLQQAQ AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP 1140
QVGYDGCQSP LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 1200
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP ELLGLTYIKG 1260
ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA ADVSGPDDEP AKLYSVHGYA 1320
STISAGSAAE GSMGDLSEIS SHSSGSHHSG SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP 1380
GSMSKPYHRQ GAVNKYVIGW KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA 1440
VAETQHVLSK EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 1500
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD GSLSDKSKCA 1560
DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH HTSYLDQRVA SFCTLTDMQH 1620
GQDLEGAQEL PLCVDPGSGK EFMDTTGERS PSPLTGKVNQ LELILRQLQT DLRKEKQDKA 1680
VLQAEVQHLR QDNMRLQEES QTATAQLRKF TEWFFTTIDK KS 1722 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR021818; DUF3401.
 IPR001478; PDZ.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF11881; DUF3401
 PF00595; PDZ
 PF02145; Rap_GAP 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ
 PS50085; RAPGAP 
PRINTS