| Tag | Content |
|---|
| CPLM ID | CPLM-013147 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transforming growth factor-beta receptor-associated protein 1 |
Protein Synonyms/Alias | TGF-beta receptor-associated protein 1; TRAP-1; TRAP1 |
Gene Name | Tgfbrap1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 334 | EEALVLAKGARRNIP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity). |
Sequence Annotation | DOMAIN 24 297 CNH.
REPEAT 564 732 CHCR. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 860 AA |
Protein Sequence | MMNIKAFTLV SAVERELLMG DRDHISIECV ECCGRNLYVG TNDCFIYHFL LEEKAMPTGT 60
ATFVATKQLH RHLGFKKPVN ELCAASALNR LLVLCDNSIT LVNMLNLEPV PSGARIKGAT 120
TFAVNESPVN GDPFCVEVCI ISVKRRTVQM FLVYEDRVQI VKEVSTPEQP LAVAVDGYFL 180
CLALTTQYII LNYSTGLSQD LFPYCSEEKP PIVKRIGRQE FLLAGPGGLG MFATVAGISQ 240
RAPVHWSENV IGAAVCFPYV IALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA 300
TSKGVYILVP LPLEKQIQDL LANRRVEEAL VLAKGARRNI PKEKFQVMYR RILQQAGFIQ 360
FAQLQFLEAK ELFRSSQLDV RELISLYPFL LPTSSSFTRS HPPLHEYADL NQLTQGDQEK 420
MAKCKRFLMS YLNEIRSTEV ANGYKEDIDT ALLKLYAEAD HDSLLDLLVT ENFCLLTDSA 480
AWLEKHKKYF ALGLLYHYNK QDASAVQLWV NIVNGDIQDS TRSDLYEYIV DFLTYCLDQE 540
LVWTHADWLL QKSEEIGVQI FTKRPLDEQQ QTSFNPDNII SSLKKYPKAL VKYLEHLVID 600
RRLQKEEYHT HLAILYLEEV LRQRVSTGGK DVEATETQAK LRRLLQKSDL YRVHLLKEKV 660
QGAGLPMESA ILHGKLGEHE KALHILVHEM GDFSAAEDYC LWSSEGQGAA CRQRLFHTLL 720
AMYLRAGPSA QDLTVAAVDL LNHHAREFDV TQVLQLLPDT WSVQLLCPFL MGAMRDSIHA 780
RRTTQVALGL AKSENLIYMY DKMKLKGNAV RLSERELCQL CQNPFGEPVF VRYPNGGLVH 840
THCAASRHTA PSSPSPGTRT 860 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:Compara. GO:0005083; F:small GTPase regulator activity; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara. GO:0007165; P:signal transduction; IEA:Compara. GO:0016192; P:vesicle-mediated transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |