UniProt Accession

 PIPNA_RAT; P16446 

Genbank Protein ID

 M25758; BC070945 

Genbank Nucleotide ID

 AAA41984.1; AAH70945.1 

Protein Name

 Phosphatidylinositol transfer protein alpha isoform 

Protein Synonyms/Alias

 PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha 

Gene Name

 Pitpna 

Gene Synonyms/Alias

 Pitpn 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MVLLKEYRVILP	acetylation	[1]
50	LVNEPYEKDDGEKGQ	acetylation	[1]
68	KIYHLQSKVPTFVRM	ubiquitination	[2]
87	GALNIHEKAWNAYPY	ubiquitination	[2]
105	VITNEYMKEDFLIKI	ubiquitination	[2]
111	MKEDFLIKIETWHKP	ubiquitination	[2]
153	DRSQVLSKDYKAEED	acetylation	[1]
153	DRSQVLSKDYKAEED	ubiquitination	[3]
163	KAEEDPAKFKSIKTG	acetylation	[1]
200	AYKLVTVKFKWWGLQ	acetylation	[1]
202	KLVTVKFKWWGLQNK	acetylation	[1]
202	KLVTVKFKWWGLQNK	ubiquitination	[2]
209	KWWGLQNKVENFIHK	acetylation	[1]
216	KVENFIHKQEKRLFT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. 

Sequence Annotation

 BINDING 59 59 Phosphatidylinositol lipid headgroup (By
 BINDING 61 61 Phosphatidylinositol lipid headgroup (By
 BINDING 86 86 Phosphatidylinositol lipid headgroup (By
 BINDING 90 90 Phosphatidylinositol lipid headgroup (By
 BINDING 97 97 Phosphatidylinositol lipid headgroup (By
 BINDING 195 195 Phosphatidylinositol lipid headgroup (By
 MOD_RES 216 216 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000062; F:fatty-acyl-CoA binding; IDA:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.
 GO:0008526; F:phosphatidylinositol transporter activity; IDA:UniProtKB.
 GO:0070540; F:stearic acid binding; IDA:UniProtKB. 

Interpro

 IPR001666; PI_transfer.
 IPR023393; START-like_dom. 

Pfam

 PF02121; IP_trans 

SMART

  

PROSITE

  

PRINTS

 PR00391; PITRANSFER.