CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001624
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Krueppel-like factor 8 
Protein Synonyms/Alias
 Basic krueppel-like factor 3; Zinc finger protein 741 
Gene Name
 KLF8 
Gene Synonyms/Alias
 BKLF3; ZNF741 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67PALFNDIKIEPPEELacetylation[1]
67PALFNDIKIEPPEELsumoylation[1, 2]
93PVDLSFHKPKAPLQPacetylation[1]
95DLSFHKPKAPLQPASacetylation[1]
Reference
 [1] Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation.
 Urvalek AM, Lu H, Wang X, Li T, Yu L, Zhu J, Lin Q, Zhao J.
 Am J Transl Res. 2011 Feb;3(2):121-32. [PMID: 21416054]
 [2] Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.
 Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J.
 J Biol Chem. 2006 Jun 16;281(24):16664-71. [PMID: 16617055] 
Functional Description
 Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). 
Sequence Annotation
 ZN_FING 274 298 C2H2-type 1.
 ZN_FING 304 328 C2H2-type 2.
 ZN_FING 334 356 C2H2-type 3.
 CROSSLNK 67 67 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT LLDANPMENP 60
ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP ASMLQAPIRP PKPQSSPQTL 120
VVSTSTSDMS TSANIPTVLT PGSVLTSSQS TGSQQILHVI HTIPSVSLPN KMGGLKTIPV 180
VVQSLPMVYT TLPADGGPAA ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG 240
SSALQSLQGL QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG 300
EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS LHRRRHDTM 359 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS