UniProt Accession

 GMHA_ECOLI; P63224; P51001 

Genbank Protein ID

 U32590; D38582; U70214; U00096; AP009048 

Genbank Nucleotide ID

 AAC43630.1; BAA07584.1; AAB08644.1; AAC73326.1; BAA77892.1 

Protein Name

 Phosphoheptose isomerase 

Protein Synonyms/Alias

 Sedoheptulose 7-phosphate isomerase 

Gene Name

 gmhA 

Gene Synonyms/Alias

 lpcA; tfrA; yafI; b0222; JW0212 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
22	ETLANFLKDDANIHA	acetylation	[1, 2]
140	AAREKGMKVITLTGK	acetylation	[2]
147	KVITLTGKDGGKMAG	acetylation	[2]
151	LTGKDGGKMAGTADI	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. 

Sequence Annotation

 DOMAIN 37 192 SIS.
 REGION 54 55 Substrate binding.
 REGION 93 94 Substrate binding (By similarity).
 REGION 119 121 Substrate binding (By similarity).
 METAL 61 61 Zinc (By similarity).
 METAL 65 65 Zinc (By similarity).
 METAL 172 172 Zinc (By similarity).
 METAL 180 180 Zinc (By similarity).
 BINDING 61 61 Substrate.
 BINDING 65 65 Substrate (By similarity).
 BINDING 120 120 Substrate.
 BINDING 124 124 Substrate (By similarity).
 BINDING 169 169 Substrate.
 BINDING 172 172 Substrate.
 BINDING 180 180 Substrate.  

Keyword

 3D-structure; Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase; Lipopolysaccharide biosynthesis; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:EcoCyc.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0008968; F:D-sedoheptulose 7-phosphate isomerase activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:2001061; P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009244; P:lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR004515; Phosphoheptose_Isoase.
 IPR001347; SIS. 

Pfam

 PF13580; SIS_2 

SMART

  

PROSITE

 PS51464; SIS 

PRINTS