CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 N6-adenosine-methyltransferase 70 kDa subunit 
Protein Synonyms/Alias
  
Gene Name
 METTL3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
206LLNTTTAKEQSIVEKubiquitination[1]
255HFRRIINKHTDESLGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
XVPTAPTSGG PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP 60
ATQDGVESLL QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA 120
GTVTGQKRRA EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN 180
QQSTKEQQSK KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA 240
DRPCRKLHFR RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS 300
QELALTQSVG GDSSADRLFP PQGHGVGERM SKSLGV 336 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:InterPro. 
Interpro
 IPR025848; MT-A70. 
Pfam
  
SMART
  
PROSITE
 PS51563; SAM_MTA70L_1 
PRINTS