| Tag | Content |
|---|
| CPLM ID | CPLM-014501 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coagulation factor X |
Protein Synonyms/Alias | Stuart factor; Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain |
Gene Name | F10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 311 | DMIIKHNKFQRDTYD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
Sequence Annotation | DOMAIN 41 85 Gla.
DOMAIN 86 122 EGF-like 1; calcium-binding (Potential).
DOMAIN 125 165 EGF-like 2.
DOMAIN 232 465 Peptidase S1.
ACT_SITE 274 274 Charge relay system (By similarity).
ACT_SITE 320 320 Charge relay system (By similarity).
ACT_SITE 417 417 Charge relay system (By similarity).
MOD_RES 46 46 4-carboxyglutamate (By similarity).
MOD_RES 47 47 4-carboxyglutamate (By similarity).
MOD_RES 54 54 4-carboxyglutamate (By similarity).
MOD_RES 56 56 4-carboxyglutamate (By similarity).
MOD_RES 59 59 4-carboxyglutamate (By similarity).
MOD_RES 60 60 4-carboxyglutamate (By similarity).
MOD_RES 65 65 4-carboxyglutamate (By similarity).
MOD_RES 66 66 4-carboxyglutamate (By similarity).
MOD_RES 69 69 4-carboxyglutamate (By similarity).
MOD_RES 72 72 4-carboxyglutamate (By similarity).
MOD_RES 75 75 4-carboxyglutamate (By similarity).
MOD_RES 79 79 4-carboxyglutamate (By similarity).
MOD_RES 103 103 (3R)-3-hydroxyaspartate (By similarity).
CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
DISULFID 57 62 By similarity.
DISULFID 90 101 By similarity.
DISULFID 95 110 By similarity.
DISULFID 112 121 By similarity.
DISULFID 129 140 By similarity.
DISULFID 136 149 By similarity.
DISULFID 151 164 By similarity.
DISULFID 172 340 Interchain (between light and heavy
DISULFID 238 243 By similarity.
DISULFID 259 275 By similarity.
DISULFID 388 402 By similarity.
DISULFID 413 441 By similarity. |
Keyword | Blood coagulation; Calcium; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; EGF-like domain; Gamma-carboxyglutamic acid; Glycoprotein; Hemostasis; Hydrolase; Hydroxylation; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 482 AA |
Protein Sequence | MESPVRLSLL YVVLASLLLP GRSVFINRER ANNVLQRIRR ANSFFEEIKK GNLERECVEE 60
ICSFEEAREV FEDNEKTTEF WNKYEDGDQC ESSPCQNQGE CRDGLGSYTC TCTEGFEGKN 120
CELFVRKLCS LDNGDCDQFC REEQNSVVCS CAKGYFLGND GKSCLSTAPF PCGKTNKGRA 180
KRSVALNTSN SEPDPEDLMP DADILYPTES PSELLNLNKT EPEANSDDVI RIVGGQECKR 240
GECPWQALLF SDEETDGFCG GTILNEFYIL TAAHCLHQAK RFKVRVGDLN TEQEDGGEMV 300
HEVDMIIKHN KFQRDTYDFD IAMLRLKTPI TFRENVAPAC LPQKDWAEAT LMTQKTGIVS 360
GFGRTHEKGR QSKVLKMMEV PYVDRNTCRL STSFSITQNM FCAGYDAKQE DACQGDSGGP 420
HVTRFKDTYF VTGIVSWGEG CARKGKYGIY TKVTAFLKWI DRSMKARVGP TSETPRLTHP 480
PY 482 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0016020; C:membrane; IDA:RGD. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:Compara. GO:0004252; F:serine-type endopeptidase activity; IDA:RGD. GO:0007596; P:blood coagulation; IDA:RGD. GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |