CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translocation protein SEC62 
Protein Synonyms/Alias
 Translocation protein 1; TP-1; hTP-1 
Gene Name
 SEC62 
Gene Synonyms/Alias
 TLOC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19QEVGEPSKEEKAVAKubiquitination[1, 2]
22GEPSKEEKAVAKYLRubiquitination[2]
35LRFNCPTKSTNMMGHubiquitination[2]
51VDYFIASKAVDCLLDubiquitination[1, 2, 3]
60VDCLLDSKWAKAKKGubiquitination[2, 4]
65DSKWAKAKKGEEALFubiquitination[2]
66SKWAKAKKGEEALFTubiquitination[1, 2]
88YCNRLLKKQFFHRALubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Required for preprotein translocation (By similarity). 
Sequence Annotation
 MOD_RES 117 117 Phosphoserine (By similarity).
 MOD_RES 158 158 Phosphothreonine.
 MOD_RES 309 309 Phosphoserine (By similarity).
 MOD_RES 313 313 Phosphoserine (By similarity).
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 343 343 Phosphothreonine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 356 356 Phosphoserine.
 MOD_RES 375 375 Phosphothreonine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS KAVDCLLDSK 60
WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM KYDKDIKKEK DKGKAESGKE 120
EDKKSKKENI KDEKTKKEKE KKKDGEKEES KKEETPGTPK KKETKKKFKL EPHDDQVFLD 180
GNEVYVWIYD PVHFKTFVMG LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL 240
LAVARCILFL IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE 300
TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED DRSQHSSGNG 360
NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKS 399 
Gene Ontology
 GO:0016235; C:aggresome; IDA:HPA.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005791; C:rough endoplasmic reticulum; ISS:UniProtKB.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006613; P:cotranslational protein targeting to membrane; TAS:ProtInc. 
Interpro
 IPR004728; Sec62. 
Pfam
 PF03839; Sec62 
SMART
  
PROSITE
  
PRINTS