UniProt Accession

 EI2BB_MOUSE; Q99LD9 

Genbank Protein ID

 AK049731; BC003326 

Genbank Nucleotide ID

 BAC33897.1; AAH03326.1 

Protein Name

 Translation initiation factor eIF-2B subunit beta 

Protein Synonyms/Alias

 eIF-2B GDP-GTP exchange factor subunit beta 

Gene Name

 Eif2b2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
237	NKVIIGTKTILANGS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.
 GO:0042552; P:myelination; ISS:UniProtKB.
 GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
 GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
 GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 

Interpro

 IPR000649; IF-2B-related. 

Pfam

 PF01008; IF-2B 

SMART

  

PROSITE

  

PRINTS