CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-032441
UniProt Accession
B9DI81_HUMAN
;
B9DI81
Genbank Protein ID
AL139246
Genbank Nucleotide ID
Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Protein Synonyms/Alias
Gene Name
PLCH2
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
468
TRQKKTM
K
LSRALSD
ubiquitination
[1]
Reference
[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [
PMID: 21906983
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Reference proteome; Transducer.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
1058 AA
Protein Sequence
MAGISDEDSL ARRQRTRDQW LKQTFDEADK NGDGSLSIGE VLQLLHKLNV NLPRQRVKQM 60
FREADTDDHQ GTLGFEEFCA FYKMMSTRRD LYLLMLTYSN HKDHLDAASL QRFLQVEQKM 120
AGVTLESCQD IIEQFEPCPE NKSKGLLGID GFTNYTRSPA GDIFNPEHHH VHQDMTQPLS 180
HYFITSSHNT YLVGDQLMSQ SRVDMYAWVL QAGCRCVEVD CWDGPDGEPI VHHGYTLTSK 240
ILFKDVIETI NKYAFIKNEY PVILSIENHC SVIQQKKMAQ YLTDILGDKL DLSSVSSEDA 300
TTLPSPQMLK GKILVKGKKL PANISEDAEE GEVSDEDSAD EIDDDCKLLN GDASTNRKRV 360
ENTAKRKLDS LIKESKIRDC EDPNNFSVST LSPSGKLGRK SKAEEDVESG EDAGASRRNG 420
RLVVGSFSRR KKKGSKLKKA ASVEEGDEGQ DSPGGQSRGA TRQKKTMKLS RALSDLVKYT 480
KSVATHDIEM EAASSWQVSS FSETKAHQIL QQKPAQYLRF NQQQLSRIYP SSYRVDSSNY 540
NPQPFWNAGC QMVALNYQSE GRMLQLNRAK FSANGGCGYV LKPGCMCQGV FNPNSEDPLP 600
GQLKKQLVLR IISGQQLPKP RDSMLGDRGE IIDPFVEVEI IGLPVDCSRE QTRVVDDNGF 660
NPTWEETLVF MVHMPEIALV RFLVWDHDPI GRDFIGQRTL AFSSMMPGYR HVYLEGMEEA 720
SIFVHVAVSD ISGKVKQALG LKGLFLRGPK PGSLDSHAAG RPPARPSVSQ RILRRTASAP 780
TKSQKPGRRG FPELVLGTRD TGSKGVADDV VPPGPGPAPE APAQEGPGSG SPRGKAPAAV 840
AEKSPVRVRP PRVLDGPGPA GMAATCMKCV VGSCAGVNTG GLQRERPPSP GPASRQAAIR 900
QQPRARADSL GAPCCGLDPH AIPGRSREAP KGPGAWRQGP GGSGSMSSDS SSPDSPGIPE 960
RSPRWPEGAC RQPGALQGEM SALFAQKLEE IRSKSPMFSA GKPLLPCVVL PHAPGMAGPG 1020
SPAAASAWTV SPRVLVLVAL YPWHCLRGTL LPWLACGP 1058
Gene Ontology
GO:0005509
; F:calcium ion binding; IEA:InterPro.
GO:0004435
; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
GO:0004871
; F:signal transducer activity; IEA:UniProtKB-KW.
GO:0035556
; P:intracellular signal transduction; IEA:InterPro.
GO:0006629
; P:lipid metabolic process; IEA:InterPro.
Interpro
IPR000008
; C2_Ca-dep.
IPR008973
; C2_Ca/lipid-bd_dom_CaLB.
IPR018029
; C2_membr_targeting.
IPR011992
; EF-hand-like_dom.
IPR018247
; EF_Hand_1_Ca_BS.
IPR002048
; EF_hand_dom.
IPR001192
; Pinositol_PLipase_C.
IPR017946
; PLC-like_Pdiesterase_TIM-brl.
IPR015359
; PLipase_C_EF-hand-like.
IPR000909
; PLipase_C_PInositol-sp_X_dom.
IPR001711
; PLipase_C_Pinositol-sp_Y.
Pfam
PF00168
; C2
PF13499
; EF_hand_5
PF09279
; efhand_like
PF00388
; PI-PLC-X
PF00387
; PI-PLC-Y
SMART
SM00239
; C2
SM00054
; EFh
SM00148
; PLCXc
SM00149
; PLCYc
PROSITE
PS50004
; C2
PS00018
; EF_HAND_1
PS50222
; EF_HAND_2
PS50007
; PIPLC_X_DOMAIN
PS50008
; PIPLC_Y_DOMAIN
PRINTS
PR00390
; PHPHLIPASEC.