CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010302
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator MurR 
Protein Synonyms/Alias
 MurPQ operon repressor 
Gene Name
 murR 
Gene Synonyms/Alias
 yfeT; b2427; JW2420 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
127LDYARLQKIIEVISKacetylation[1]
195AISYSGSKKEIVLCAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription. 
Sequence Annotation
 DOMAIN 1 77 HTH rpiR-type.
 DOMAIN 128 268 SIS.
 DNA_BIND 37 56 H-T-H motif (Potential).  
Keyword
 Carbohydrate metabolism; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MLYLTKISNA GSEFTENEQK IADFLQANVS ELQSVSSRQM AKQLGISQSS IVKFAQKLGA 60
QGFTELRMAL IGEYSASREK TNATALHLHS SITSDDSLEV IARKLNREKE LALEQTCALL 120
DYARLQKIIE VISKAPFIQI TGLGGSALVG RDLSFKLMKI GYRVACEADT HVQATVSQAL 180
KKGDVQIAIS YSGSKKEIVL CAEAARKQGA TVIAITSLTD SPLRRLAHFT LDTVSGETEW 240
RSSSMSTRTA QNSVTDLLFV GLVQLNDVES LKMIQRSSEL TQRLK 285 
Gene Ontology
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
 GO:0097173; P:N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0043470; P:regulation of carbohydrate catabolic process; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000281; HTH_RpiR.
 IPR001347; SIS.
 IPR022821; Tscrpt_reg_HTH_MurR.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01418; HTH_6
 PF01380; SIS 
SMART
  
PROSITE
 PS51071; HTH_RPIR
 PS51464; SIS 
PRINTS